{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:35:49Z","timestamp":1767846949791,"version":"3.49.0"},"reference-count":83,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T00:00:00Z","timestamp":1313107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2011) <jats:bold>118<\/jats:bold>, 1075\u20131086.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The reactive oxygen species (ROS) superoxide has been recognized as a critical signal triggering retinal ganglion cell (RGC) death after axonal injury. Although the downstream targets of superoxide are unknown, chemical reduction of oxidized sulfhydryls has been shown to be neuroprotective for injured RGCs. On the basis of this, we developed novel phosphine\u2010borane complex compounds that are cell permeable and highly stable. Here, we report that our lead compound, bis (3\u2010propionic acid methyl ester) phenylphosphine borane complex 1 (PB1) promotes RGC survival in rat models of optic nerve axotomy and in experimental glaucoma. PB1\u2010mediated RGC neuroprotection did not correlate with inhibition of stress\u2010activated protein kinase signaling, including apoptosis stimulating kinase 1 (ASK1), <jats:italic>c\u2010jun<\/jats:italic> NH2\u2010terminal kinase (JNK) or p38. Instead, PB1 led to a striking increase in retinal BDNF levels and downstream activation of the extracellular signal\u2010regulated kinases 1\/2 (ERK1\/2) pathway. Pharmacological inhibition of ERK1\/2 entirely blocked RGC neuroprotection induced by PB1. We conclude that PB1 protects damaged RGCs through activation of pro\u2010survival signals. These data support a potential cross\u2010talk between redox homeostasis and neurotrophin\u2010related pathways leading to RGC survival after axonal injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07382.x","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T20:57:44Z","timestamp":1310504264000},"page":"1075-1086","source":"Crossref","is-referenced-by-count":42,"title":["A cell\u2010permeable phosphine\u2010borane complex delays retinal ganglion cell death after axonal injury through activation of the pro\u2010survival extracellular signal\u2010regulated kinases 1\/2 pathway"],"prefix":"10.1111","volume":"118","author":[{"given":"Mohammadali","family":"Almasieh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Lieven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard A.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Di Polo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171331"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301089200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1995.1015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902510208"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzg088"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1996.0175"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00138-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb38704.x"},{"key":"e_1_2_7_11_1","first-page":"2969","article-title":"Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure\u2010induced rat model of optic nerve damage","volume":"43","author":"Chauhan B. 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