{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:55:53Z","timestamp":1773662153031,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T00:00:00Z","timestamp":1313971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic>(2011)<jats:bold>119<\/jats:bold>, 210\u2013219.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>We previously reported that propofol (20\u2003mg\/kg\/h) post\u2010conditioning provided acute (up to 24\u2003h) neuroprotection in rats with transient middle cerebral artery occlusion. In this study, we extend these data by examining long\u2010term protection and exploring underlying mechanisms involving AMPA receptor GluR2 subunit internalization. Rats were treated with propofol 20\u2003mg\/kg\/h after 60\u2003min of occlusion (beginning of reperfusion for 4\u2003h). Propofol post\u2010conditioning reduced infarct volume and improved spatial memory deficiencies (up to 28\u2003days) induced by ischemia\/reperfusion injury. Additionally, Propofol post\u2010conditioning promoted neurogenesis in the dentate gyrus of hippocampus, as measured by bromodeoxyuridine and neuron\u2010specific nuclear protein immunofluorescence\u2010double staining at day 28 after reperfusion. Finally, propofol post\u2010conditioning increased the surface expression of AMPA receptor GluR2 subunit, thus inhibited the internalization of this part until 28\u2003days after stroke. In conclusion, our data suggest that propofol post\u2010conditioning provides long\u2010term protection against focal cerebral ischemia\/reperfusion injury in rats. Furthermore, we found that the inhibition of AMPA receptor GluR2 subunit internalization may contributed to this long\u2010term neuroprotection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07400.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T13:53:12Z","timestamp":1311688392000},"page":"210-219","source":"Crossref","is-referenced-by-count":54,"title":["Propofol post\u2010conditioning induced long\u2010term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia\/reperfusion"],"prefix":"10.1111","volume":"119","author":[{"given":"Haiyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.9.1616"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn920"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01147-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2002.00991.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00096-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90279-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.09.022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2252-05.2005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380604"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80113-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03371-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-08-02493.1990"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0166-2236(95)80018-W","article-title":"Calcium: still center\u2010stage in hypoxic\u2013ischemic neuronal death","volume":"18","author":"Choi D. W.","year":"1995","journal-title":"Trends Neurosci."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb05807.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90054-U"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0031-6997(24)01394-2","article-title":"The glutamate receptor ion channels","volume":"51","author":"Dingledine R.","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/381071a0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.04.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200410000-00016"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90076-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-16-06179.1997"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12479.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991011)413:1<146::AID-CNE10>3.0.CO;2-B"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.17.030194.000335"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1709304"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1653450"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90087-X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90444-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00337-I"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.3.530"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-02027.1996"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.06.034"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0567-06.2006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.02.027"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.210350097"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb17509.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02100.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324002"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.025"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-07922.2000"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem119"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90081-W"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.8.4226"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.05.016"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190202"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00062-3"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200203000-00007"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10378"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.488445"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1710829"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.116"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.054"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-01982.1996"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05276.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(98)00067-3"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.337"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600348"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2011.07400.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2011.07400.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:06:49Z","timestamp":1741352809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2011.07400.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,22]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1471-4159.2011.07400.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07400.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,22]]}}}