{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:54:31Z","timestamp":1791093271850,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2011) <jats:bold>119<\/jats:bold>, 262\u2013274.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:italic>Cone\u2010rod homeobox<\/jats:italic> (<jats:italic>Crx<\/jats:italic>) encodes Crx, a transcription factor expressed selectively in retinal photoreceptors and pinealocytes, the major cell type of the pineal gland. In this study, the influence of Crx on the mammalian pineal gland was studied by light and electron microscopy and by use of microarray and qRTPCR technology, thereby extending previous studies on selected genes (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b16\">Furukawa <jats:italic>et\u00a0al.<\/jats:italic> 1999<\/jats:ext-link>). Deletion of <jats:italic>Crx<\/jats:italic> was not found to alter pineal morphology, but was found to broadly modulate the mouse pineal transcriptome, characterized by a\u2003&gt;\u20032\u2010fold down\u2010regulation of 543 genes and a\u2003&gt;\u20032\u2010fold up\u2010regulation of 745 genes (<jats:italic>p\u2003<\/jats:italic>&lt;\u20030.05). Of these, one of the most highly up\u2010regulated (18\u2010fold) was <jats:italic>Hoxc4<\/jats:italic>, a member of the Hox gene family, members of which are known to control gene expression cascades. During a 24\u2010h period, a set of 51 genes exhibited differential day\/night expression in pineal glands of wild\u2010type animals; only eight of these were also day\/night expressed in the <jats:italic>Crx<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> pineal gland. However, in the <jats:italic>Crx<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> pineal gland 41 genes exhibited differential night\/day expression that was not seen in wild\u2010type animals. These findings indicate that <jats:italic>Crx<\/jats:italic> broadly modulates the pineal transcriptome and also influences differential night\/day gene expression in this tissue. Some effects of Crx deletion on the pineal transcriptome might be mediated by <jats:italic>Hoxc4<\/jats:italic> up\u2010regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07405.x","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T06:54:35Z","timestamp":1311922475000},"page":"262-274","source":"Crossref","is-referenced-by-count":29,"title":["Crx broadly modulates the pineal transcriptome"],"prefix":"10.1111","volume":"119","author":[{"given":"Louise","family":"Rovsing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Clokie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego M.","family":"Bustos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Coon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Litman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/npep.1999.0779"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.03.021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0121"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808394200"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00555.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00162-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0519"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80394-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.5.E792"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020683"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.12.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80439-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/70591"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1242\/dev.116.2.497","article-title":"Sequence and embryonic expression of the murine Hox\u20103.5 gene","volume":"116","author":"Geada A. 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