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Neurochem.<\/jats:italic> (2011) <jats:bold>119<\/jats:bold>, 408\u2013416.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>In addition to genetic aspects, environmental factors such as stress may also play a critical role in the etiology of the late onset, sporadic Alzheimer\u2019s disease (AD). The present study examined the effect of chronic psychosocial stress in a sub\u2010threshold A\u03b2 (subA\u03b2) rat model of AD on long\u2010term depression by two techniques: electrophysiological recordings of synaptic plasticity in anesthetized rats, and immunoblot analysis of memory\u2010 and AD\u2010related signaling molecules. Chronic psychosocial stress was induced using a rat intruder model. The subA\u03b2 rat model of AD, which was intended to represent outwardly normal individuals with a pre\u2010disposition to AD, was induced by continuous infusion of 160\u2003pmol\/day A\u03b2<jats:sub>1\u201042<\/jats:sub> via a 14\u2010day i.c.v. osmotic pump. Results from electrophysiological recordings showed that long\u2010term depression evoked in stress\/subA\u03b2 animals was significantly enhanced compared with that in animals exposed to stress or subA\u03b2 infusion alone. Molecular analysis of various signaling molecules 1\u2003h after induction of long\u2010term depression revealed an increase in the levels of calcineurin and phosphorylated CaMKII in groups exposed to stress compared with other groups. The levels of the brain\u2010derived neurotrophic factor (BDNF) were significantly decreased in stress\/subA\u03b2 animals but not in stress or subA\u03b2 animals. In addition, the levels of beta\u2010site amyloid precursor protein cleaving enzyme were markedly increased in stress\/subA\u03b2. These findings suggest that chronic stress may accelerate the impairment of synaptic plasticity and consequently cognition in individuals \u2018at\u2010risk\u2019 for AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07437.x","type":"journal-article","created":{"date-parts":[[2011,8,20]],"date-time":"2011-08-20T10:37:35Z","timestamp":1313836655000},"page":"408-416","source":"Crossref","is-referenced-by-count":21,"title":["Chronic psychosocial stress enhances long\u2010term depression in a subthreshold amyloid\u2010beta rat model of Alzheimer\u2019s disease"],"prefix":"10.1111","volume":"119","author":[{"given":"Trinh T.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Srivareerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Alhaider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim A.","family":"Alkadhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.070"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20716"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.12.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.05.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720511797633188"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.01.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.06.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2010.06.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002101"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00125-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199710200-00006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.6119"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03181-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10193"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.04.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2797-06.2006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324290"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720507780362083"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07091532"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05769.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1403.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90014-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90009-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.071"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07767"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)01002-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90273-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/196"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264307300975"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351219"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31034-3"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.02.016"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1782"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340600"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.021"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.015"},{"key":"e_1_2_7_41_1","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1152\/jn.1996.76.3.2097","article-title":"Distinct synaptic loci of Ca2+\/calmodulin\u2010dependent protein kinase II necessary for long\u2010term potentiation and depression","volume":"76","author":"Stanton P. 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