{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:30:49Z","timestamp":1789000249939,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T00:00:00Z","timestamp":1320192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>J. Neurochem.<\/jats:italic>\n                      (2011) 10.1111\/j.1471\u20104159.2011.07530.x\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Oxygen\u2010induced retinopathy (OIR) is a model for human retinopathy of prematurity. In mice with OIR, beta\u2010adrenergic receptor (\u03b2\u2010AR) blockade with propranolol has been shown to ameliorate different aspects of retinal dysfunction in response to hypoxia. In the present study, we used the OIR model to investigate the role of distinct \u03b2\u2010ARs on retinal proangiogenic factors, pathogenic neovascularization and electroretinographic responses. Our results demonstrate that \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010AR blockade with ICI 118,551 decreases retinal levels of proangiogenic factors and reduces pathogenic neovascularization, whereas \u03b2\n                      <jats:sub>1<\/jats:sub>\n                      \u2010 and \u03b2\n                      <jats:sub>3<\/jats:sub>\n                      \u2010AR antagonists do not. Determination of retinal protein kinase A activity is indicative of the fact that \u03b2\u2010AR blockers are indeed effective at the receptor level. In addition, the specificity of ICI 118,551 on retinal angiogenesis has been demonstrated by the finding that in mouse retinal explants, \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010AR silencing prevents ICI 118,551 effects on hypoxia\u2010induced vascular endothelial growth factor accumulation. In OIR mice, ICI 118,551 is effective in increasing electroretinographic responses suggesting that activation of \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010ARs constitutes an important part of the retinal response to hypoxia. Lastly, immunohistochemical studies demonstrate that \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010ARs are localized to several retinal cells, particularly to M\u00fcller cells suggesting the possibility that \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010ARs play a role in regulating vascular endothelial growth factor production by these cells. The present results suggest that pathogenic angiogenesis, a key change in many hypoxic\/ischemic vision\u2010threatening retinal diseases, depends at least in part on \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010AR activity and indicate that \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010AR blockade can be effective against retinal angiogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07530.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T14:49:54Z","timestamp":1318344594000},"page":"1317-1329","source":"Crossref","is-referenced-by-count":79,"title":["Antiangiogenic effects of \u03b2\n                    <sub>2<\/sub>\n                    \u2010adrenergic receptor blockade in a mouse model of oxygen\u2010induced retinopathy"],"prefix":"10.1111","volume":"119","author":[{"given":"Davide","family":"Martini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo Dal","family":"Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ristori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cupisti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Fiorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.02.002"},{"key":"e_1_2_8_3_1","first-page":"2499","article-title":"The neurovascular relation in oxygen\u2010induced retinopathy","volume":"14","author":"Akula J. D.","year":"2008","journal-title":"Mol. Vis."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.03.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2611"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1096"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7907"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060070065030"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911661107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1469"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00562.2003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.05.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-10-83"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.06.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.07.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-003-0860-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2961"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4779"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.04.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705665"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.161570"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107424"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2010.08.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.048249"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0702"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.86"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00773-6"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2006.01.006"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp008003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(98)00157-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381298-8.00011-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0892"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5536"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602404"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00595.2009"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0113"},{"key":"e_1_2_8_41_1","first-page":"101","article-title":"Oxygen\u2010induced retinopathy in the mouse","volume":"35","author":"Smith L. E.","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.08.018"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300368200"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.08.015"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190802442070"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.12.015"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200304000-00003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22530"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-006-0127-5"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0129"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.03.012"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1023"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.09.018"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490503375"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.10.008"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20942"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.03.019"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.087"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01073.2009"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.12.013"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.057"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.2011.07530.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.2011.07530.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:20:14Z","timestamp":1696659614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.2011.07530.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,2]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1471-4159.2011.07530.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07530.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,2]]}}}