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Neurochem.<\/jats:italic>(2012)<jats:bold>120<\/jats:bold>, 779\u2013794.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Mu opioid receptors are densely expressed in the patch compartment of striatum and contribute to methamphetamine\u2010induced patch\u2010enhanced gene expression and stereotypy. To further elucidate the role of mu opioid receptor activation in these phenomena, we examined whether activation of mu opioid receptors would enhance methamphetamine\u2010induced stereotypy and prodynorphin,<jats:italic>c\u2010fos<\/jats:italic>,<jats:italic>arc<\/jats:italic>and<jats:italic>zif\/268<\/jats:italic>expression in the patch and\/or matrix compartments of striatum, as well as the impact of mu opioid receptor activation on the relationship between patch\u2010enhanced gene expression and stereotypy. Male Sprague\u2013Dawley rats were intrastriatally infused with<jats:sc>d<\/jats:sc>\u2010Ala(2)\u2010N\u2010Me\u2010Phe(4),Gly(5)\u2010ol]enkephalin (DAMGO; 1\u2003\u03bcg\/\u03bcL), treated with methamphetamine (0.5\u2003mg\/kg) and killed at 45\u2003min or 2\u2003h later. DAMGO augmented methamphetamine\u2010induced<jats:italic>zif\/268<\/jats:italic>mRNA expression in the patch and matrix compartments, while prodynorphin expression was increased in the dorsolateral patch compartment. DAMGO pre\u2010treatment did not affect methamphetamine\u2010induced<jats:italic>arc<\/jats:italic>and<jats:italic>c\u2010fos<\/jats:italic>expression. DAMGO enhanced methamphetamine\u2010induced stereotypy and resulted in greater patch versus matrix expression of prodynorphin in the dorsolateral striatum, leading to a negative correlation between the two. These findings indicate that mu opioid receptors contribute to methamphetamine\u2010induced stereotypy, but can differentially influence the genomic responses to methamphetamine. These data also suggest that prodynorphin may offset the overstimulation of striatal neurons by methamphetamine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2011.07620.x","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T20:46:07Z","timestamp":1323377167000},"page":"779-794","source":"Crossref","is-referenced-by-count":15,"title":["Activation of mu opioid receptors in the striatum differentially augments methamphetamine\u2010induced gene expression and enhances stereotypic behavior"],"prefix":"10.1111","volume":"120","author":[{"given":"Kristen A.","family":"Horner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Hebbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golda A.","family":"Vanchipurakel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamiece E.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00640-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00530-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01507.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06907.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90073-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.10.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/73949"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1523\/JNEUROSCI.22-14-06218.2002","article-title":"Concurrent activation of dopamine D1 and D2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization","volume":"22","author":"Capper\u2010Loup C.","year":"2002","journal-title":"J. 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