{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:20:22Z","timestamp":1768814422079,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2012) <jats:bold>121<\/jats:bold>, 438\u2013450.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>In neurons exposed to glutamate, Ca<jats:sup>2+<\/jats:sup> influx triggers intracellular Zn<jats:sup>2+<\/jats:sup> release via an as yet unclear mechanism. As glutamate induces a Ca<jats:sup>2+<\/jats:sup>\u2010dependent cytosolic acidification, the present work tested the relationships among intracellular Ca<jats:sup>2+<\/jats:sup> concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>), intracellular pH (pH<jats:sub>i<\/jats:sub>), and [Zn<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>. Cultured hippocampal neurons were exposed to glutamate and glycine (Glu\/Gly), while [Zn<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and pH<jats:sub>i<\/jats:sub> were monitored using FluoZin\u20103, Fura2\u2010FF, and 2\u2032,7\u2032\u2010bis\u2010(2\u2010carboxyethyl)\u20105(6)\u2010carboxyfluorescein, respectively. Glu\/Gly applications decreased pH<jats:sub>i<\/jats:sub> to 6.1 and induced intracellular Zn<jats:sup>2+<\/jats:sup> release in a Ca<jats:sup>2+<\/jats:sup>\u2010dependent manner, as expected. The pH<jats:sub>i<\/jats:sub> drop reduced the affinity of FluoZin\u20103 and Fura\u20102\u2010FF for Zn<jats:sup>2+<\/jats:sup>. The rate of Glu\/Gly\u2010induced [Zn<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> increase was not correlated with the rate of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> increase. Instead, the extent of [Zn<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> elevations corresponded well to the rate of pH<jats:sub>i<\/jats:sub> drop. Namely, [Zn<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> increased more in more highly acidified neurons. Inhibiting the mechanisms responsible for the Ca<jats:sup>2+<\/jats:sup>\u2010dependent pH<jats:sub>i<\/jats:sub> drop (plasmalemmal Ca<jats:sup>2+<\/jats:sup> pump and mitochondria) counteracted the Glu\/Gly\u2010induced intracellular Zn<jats:sup>2+<\/jats:sup> release. Alkaline pH (8.5) suppressed Glu\/Gly\u2010induced intracellular Zn<jats:sup>2+<\/jats:sup> release whereas acidic pH (6.0) enhanced it. A pH<jats:sub>i<\/jats:sub> drop to 6.0 (without any Ca<jats:sup>2+<\/jats:sup> influx or glutamate receptor activation) led to intracellular Zn<jats:sup>2+<\/jats:sup> release; the released Zn<jats:sup>2+<\/jats:sup> (free Zn<jats:sup>2+<\/jats:sup> plus Zn<jats:sup>2+<\/jats:sup> bound to Fura\u20102FF and FluoZin\u20103) reached 1\u2003\u03bcM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2012.07695.x","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T19:46:29Z","timestamp":1329421589000},"page":"438-450","source":"Crossref","is-referenced-by-count":32,"title":["Cytosolic acidification and intracellular zinc release in hippocampal neurons"],"prefix":"10.1111","volume":"121","author":[{"given":"Lech","family":"Kiedrowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306766200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0751878.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00150-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2007.10.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00015-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.18.13441"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66010403.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67062282.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(92)90066-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.183"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00143.2001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.10.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.3.618"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05536.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900501200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00047.Frazzini"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00399-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91835-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja011774y"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-11-04690.1993"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.17"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.1999.0092"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1523\/JNEUROSCI.14-03-01352.1994","article-title":"N\u2010Methyl\u2010D\u2010aspartate induces a rapid, reversible, and calcium dependent intracellular acidosis in cultured fetal rat hippocampal neurons","volume":"14","author":"Irwin R. 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