{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:31:33Z","timestamp":1792222293935,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2012) <jats:bold>121<\/jats:bold>, 891\u2013902.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Signal regulatory protein \u03b1 (SIRP\u03b1) is a neuronal membrane protein that undergoes tyrosine phosphorylation in the brain of mice in response to forced swim (FS) stress in cold water, and this response is implicated in regulation of depression\u2010like behavior in the FS test. We now show that subjection of mice to the FS in warm (37\u00b0C) water does not induce the tyrosine phosphorylation of SIRP\u03b1 in the brain. The rectal temperature (<jats:italic>T<\/jats:italic><jats:sub>rec<\/jats:sub>) of mice was reduced to 27\u00b0 to 30\u00b0C by performance of the FS for 10\u2003min in cold water, whereas it was not affected by the same treatment in warm water. The level of tyrosine phosphorylation of SIRP\u03b1 in the brain was increased by administration of ethanol or picrotoxin, starvation, or cooling after anesthesia, all of which also induced hypothermia. Furthermore, the tyrosine phosphorylation of SIRP\u03b1 in cultured hippocampal neurons was induced by lowering the temperature of the culture medium. CD47, a ligand of SIRP\u03b1, as well as Src family kinases or SH2 domain\u2010containing protein phosphatase 2 (Shp2), might be important for the basal and the hypothermia\u2010induced tyrosine phosphorylation of SIRP\u03b1. Hypothermia is therefore likely an important determinant of both the behavioral immobility and tyrosine phosphorylation of SIRP\u03b1 observed in the FS test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2012.07748.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T16:59:49Z","timestamp":1333472389000},"page":"891-902","source":"Crossref","is-referenced-by-count":10,"title":["Hypothermia\u2010induced tyrosine phosphorylation of SIRP\u03b1 in the 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