{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:53:45Z","timestamp":1776092025065,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:00:00Z","timestamp":1334793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2012) <jats:bold>122<\/jats:bold>, 19\u201323.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The concept that the immune system plays a central role in the pathogenesis of multiple sclerosis (MS) and neuromyelitis optica (NMO) was indisputable. However, neurodegenerative pathological features including loss of axons and neurons were also found in the lesions of these diseases. \u03b1\u2010Synuclein is one of the most abundant proteins in pre\u2010synaptic terminals. Recently, many research show \u03b1\u2010synuclein level in CSF may reflect the progression of synaptic dysfunction and neuronal apoptosis. Whether the levels of CSF \u03b1\u2010synuclein are changed in MS and NMO patients remain unknown. In this study, CSF \u03b1\u2010synuclein was measured by an enzyme\u2010linked immunosorbent assay (ELISA) in MS (<jats:italic>n<\/jats:italic>\u2003=\u200318) patients, NMO (<jats:italic>n<\/jats:italic>\u2003=\u200322) patients, Parkinson\u2019s disease patients (<jats:italic>n<\/jats:italic>\u2003=\u20039), and the controls (<jats:italic>n<\/jats:italic>\u2003=\u200311). We found concentration of \u03b1\u2010synuclein in MS and NMO patients were significantly higher than Parkinson\u2019s disease subgroup and the controls. Both MS and NMO revealed an increased disease disability with increased CSF \u03b1\u2010synuclein. Thus, CSF \u03b1\u2010synuclein may be reflect injure axons and neurons in inflammatory demyelinating diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2012.07749.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T16:59:52Z","timestamp":1333472392000},"page":"19-23","source":"Crossref","is-referenced-by-count":30,"title":["Cerebrospinal fluid \u03b1\u2010synuclein levels are elevated in multiple sclerosis and neuromyelitis optica patients during replase"],"prefix":"10.1111","volume":"122","author":[{"given":"Honghao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<120::AID-JNR12>3.0.CO;2-E"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07199.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.368"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22499"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.03.026"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00395-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350923"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.10.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.308"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318196e905"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf151"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61755-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70014-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7929"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.01.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06831.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000321342","article-title":"\u03b1\u2010Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia","volume":"32","author":"Su E.","year":"2010","journal-title":"Dev. 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