{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:39:41Z","timestamp":1792093181503,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2012) <jats:bold>122<\/jats:bold>, 404\u2013414.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Alpha\u2010synuclein (\u03b1\u2010syn) is a synaptic protein that mutations have been linked to Parkinson\u2019s disease (PD), a common neurodegenerative disorder that is caused by the degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc). How \u03b1\u2010syn can contribute to neurodegeneration in PD is not conclusive but it is agreed that mutations or excessive accumulation of \u03b1\u2010syn can lead to the formation of \u03b1\u2010syn oligomers or aggregates that interfere with normal cellular function and contribute to the degeneration of dopaminergic neurons. In this study, we found that \u03b1\u2010syn can impair the normal dynamics of mitochondria and this effect is particular prominent in A53T \u03b1\u2010syn mutant. In mice expressing A53T \u03b1\u2010syn, age\u2010dependent changes in both mitochondrial morphology and proteins that regulate mitochondrial fission and fusion were observed. In the cellular model of PD, we found that \u03b1\u2010syn reduces the movement of mitochondria in both SH\u2010SY5Y neuroblastoma and hippocampal neurons. Taken together, our study provides a new mechanism of how \u03b1\u2010syn can contribute to PD through the impairment of normal dynamics of mitochondria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2012.07769.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T16:31:39Z","timestamp":1335457899000},"page":"404-414","source":"Crossref","is-referenced-by-count":135,"title":["Alpha\u2010synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson\u2019s disease"],"prefix":"10.1111","volume":"122","author":[{"given":"Weilin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny K. 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