{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:15:56Z","timestamp":1781151356985,"version":"3.54.1"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>J. Neurochem.<\/jats:italic> (2012) <jats:bold>122<\/jats:bold>, 501\u2013511.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Up\u2010regulation of neurotrophin synthesis is an important mechanism of peripheral nerve regeneration after injury. Neurotrophin expression is regulated by a complex series of events including cell interactions and multiple molecular stimuli. We have studied neurotrophin synthesis at 2\u2003weeks time\u2010point in a transvertebral model of unilateral or bilateral transection of sciatic nerve in rats. We have found that unilateral sciatic nerve transection results in the elevation of nerve growth factor (NGF) and NT\u20103, but not glial cell\u2010line derived neurotrophic factor or brain\u2010derived neural factor, in the uninjured nerve on the contralateral side, commonly considered as a control. Bilateral transection further increased NGF but not other neurotrophins in the nerve segment distal to the transection site, as compared to the unilateral injury. To further investigate the distinct role of NGF in regeneration and its potential for peripheral nerve repair, we transduced isogeneic Schwann cells with NGF\u2010encoding lentivirus and transplanted the over\u2010expressing cells into the distal segment of a transected nerve. Axonal regeneration was studied at 2\u2003weeks time\u2010point using pan\u2010neuronal marker NF\u2010200 and found to directly correlate with NGF levels in the regenerating nerve.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1471-4159.2012.07792.x","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T10:43:10Z","timestamp":1337596990000},"page":"501-511","source":"Crossref","is-referenced-by-count":34,"title":["Evidence for a systemic regulation of neurotrophin synthesis in response to peripheral nerve injury"],"prefix":"10.1111","volume":"122","author":[{"given":"Antos","family":"Shakhbazau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Gui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Kawasoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"van Minnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Midha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90265-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb04835.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.10.017"},{"key":"e_1_2_9_6_1","first-page":"327","article-title":"Retrograde injury signaling in lesioned axons","volume":"48","author":"Ben\u2010Yaakov K.","year":"2009","journal-title":"Results Probl. 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