{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:00:12Z","timestamp":1760853612757},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) is a devastating neurodegenerative disorder caused by an expansion of <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> trinucleotide repeats encoding for polyglutamine (polyQ) in the huntingtin (<jats:styled-content style=\"fixed-case\">Htt<\/jats:styled-content>) gene. Despite considerable effort, the mechanisms underlying the toxicity of the mutated Htt protein remains largely uncertain. To identify novel therapeutic targets, we recently employed the approach of tandem affinity purification and discovered that calretinin (Cr), a member of the <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\u2010hand family of calcium\u2010binding proteins, is preferentially associated with mHtt, although it also interacts with wild\u2010type Htt. These observations were supported by coimmunoprecipitation and by colocalization of Cr with mHtt in neuronal cultures. Over\u2010 expression of Cr reduced mHtt\u2010caused cytotoxicity in both non\u2010neuronal and neuronal cell models of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>, whereas knockdown of Cr expression in the cells enhanced mHtt\u2010caused neuronal cell death. In addition, over\u2010expression of Cr was also associated with reduction of intracellular free calcium and activation of Akt. These results suggest that Cr may be a potential therapeutic target for treatment of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2012.07919.x","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T15:17:42Z","timestamp":1344957462000},"page":"437-446","source":"Crossref","is-referenced-by-count":19,"title":["Calretinin interacts with huntingtin and reduces mutant huntingtin\u2010caused cytotoxicity"],"prefix":"10.1111","volume":"123","author":[{"given":"Gaofeng","family":"Dong","sequence":"first","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota Vermillion South Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Biology Mount Marty College Yankton South Dakota 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