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To identify the individual miRNAs that are altered in HD and may therefore regulate a gene network underlying mutant huntingtin\u2010induced neuronal dysfunction in HD, we performed miRNA array analysis combined with <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> profiling in the cerebral cortex from N171\u201082Q HD mice. Expression profiles of miRNAs as well as <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s in HD mouse cerebral cortex were analyzed and confirmed at different stages of disease progression; the most significant changes of miRNAs in the cerebral cortex were also detected in the striatum of HD mice. Our results revealed a significant alteration of miR\u2010200 family members, miR\u2010200a, and miR\u2010200c in the cerebral cortex and the striatum, at the early stage of disease progression in N171\u201082Q HD mice. We used a coordinated approach to integrate miRNA and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> profiling, and applied bioinformatics to predict a target gene network potentially regulated by these significantly altered miRNAs that might be involved in HD disease progression. Interestingly, miR\u2010200a and miR\u2010200c are predicted to target genes regulating synaptic function, neurodevelopment, and neuronal survival. Our results suggest that altered expression of miR\u2010200a and miR\u2010200c may interrupt the production of proteins involved in neuronal plasticity and survival, and further investigation of the involvement of perturbed miRNA expression in HD pathogenesis is warranted, and may lead to reveal novel approaches for HD therapy.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2012.07925.x","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T10:53:09Z","timestamp":1345546389000},"page":"477-490","source":"Crossref","is-referenced-by-count":54,"title":["Interrogation of brain miRNA and <scp>mRNA<\/scp> expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin"],"prefix":"10.1111","volume":"123","author":[{"given":"Jing","family":"Jin","sequence":"first","affiliation":[{"name":"Division of Neurobiology Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Neurobiology Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gene Expression and Genomics Unit Research Resources Branch National Institute on Aging Intramural Research Program Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wood","sequence":"additional","affiliation":[{"name":"Gene Expression and Genomics Unit Research Resources Branch National Institute on Aging Intramural Research Program Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Neurobiology Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmette","family":"Hutchison","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences National Institute on Aging Intramural Research Program Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Mattson","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences National Institute on Aging Intramural Research Program Baltimore Maryland USA"},{"name":"Department of Neuroscience Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Becker","sequence":"additional","affiliation":[{"name":"Gene Expression and Genomics Unit Research Resources Branch National Institute on Aging Intramural Research Program Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Duan","sequence":"additional","affiliation":[{"name":"Division of Neurobiology Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Program in Cellular and Molecular Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420213"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00449-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.783108"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802261105"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg325"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.24.3579"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81736-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1806"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1242\/jcs.114.2.445","article-title":"The synaptic vesicle protein, cysteine\u2010string protein, is associated with the plasma membrane in 3T3\u2010L1 adipocytes and interacts with syntaxin 4","volume":"114","author":"Chamberlain L. 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