{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:36:56Z","timestamp":1778143016040,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,31]],"date-time":"2005-03-31T00:00:00Z","timestamp":1112227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental studies indicate that ischemia\/reperfusion (I\/R) causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative injury on testicular damage following myocardial I\/R injury and the effects of antioxidant agents, melatonin and caffeic acid phenethyl ester (CAPE), on testicular injury were investigated. As far as we know, this is the first report demonstrating that myocardial I\/R induces damage to the testes. Thirty\u2010two male Wistar rats were randomly divided into four groups: sham operation (SO), I\/R\u2003+\u2003vehicle, I\/R\u2003+\u2003melatonin, and I\/R\u2003+\u2003caffeic acid phenethyl ester. To produce cardiac damage, the left main coronary artery was occluded for 30\u2003min, followed by 120\u2003min reperfusion, in anesthetized rats. Serum nitric oxide (NO) and malondialdehyde (MDA) levels and morphological changes were examined. I\/R was accompanied by a significant increase in serum MDA and NO levels, whereas, melatonin and CAPE administration significantly reduced these values. Melatonin was more efficient in reducing MDA levels than CAPE (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). I\/R induced myocardial damage, manifested as the histopathological evidence of intracellular vacuolization, interstitial edema, neutrophil infiltration and coagulative necrosis. I\/R\u2003+\u2003vehicle group showed many histological alterations such as focal tubular atrophy, and degeneration and disorganization of the seminiferous epithelium in testes. The number of atrophic tubules and degenerating cells was significantly higher in I\/R\u2003+\u2003vehicle group than that of SO group. Melatonin and CAPE significantly reduced the number of degenerating cells; additionally, melatonin reduced the number of atrophic tubules (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Our results indicate that myocardial I\/R induces severe testicular damage and antioxidant agents, especially melatonin, have protective effects on testicular injury after myocardial I\/R. Our data emphasize that oxygen\u2010based reactants may play a central role in remote organ injury.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2005.00331.x","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T23:43:11Z","timestamp":1117755791000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of melatonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia\/reperfusion in rats"],"prefix":"10.1111","volume":"19","author":[{"given":"Mukaddes","family":"E\u015frefo\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Parlakpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Acet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00159.2002"},{"key":"e_1_2_5_3_2","first-page":"350","article-title":"ICAM\u20101 upregulation in distant tissues after hepatic ischemia\/reperfusion: a clue to the mechanism of multiple organ failure","volume":"33","author":"Meyer K.","year":"1998","journal-title":"J. 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