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Also, they were investigated when administration of<jats:sc>l<\/jats:sc>\u2010NAME was preceded by peripheral autonomic blockade. Autonomic blockade had different forms: ganglionic (hexamethonium\u2010induced), post\u2010ganglionic<jats:italic>\u03b2<\/jats:italic>\u2010adrenergic blockade (propranolol induced), parasympathetic blockade (atropine induced), and complete autonomic blockade by coadministration of hexamethonium and atropine simultaneously.<jats:sc>l<\/jats:sc>\u2010NAME injected intravenously (10\u2003mg\/kg) in animals with intact and blocked autonomic activity induced a pressor response. This pressor response was accompanied by bradycardia in rabbits with either intact autonomic activity or hexamethonium\u2010induced ganglionic blockade.<jats:sc>l<\/jats:sc>\u2010NAME exerted no effect on heart rate in animals with<jats:italic>\u03b2<\/jats:italic>\u2010adrenergic blockade or parasympathetic blockade. In rabbits with complete autonomic blockade,<jats:sc>l<\/jats:sc>\u2010NAME evoked tachycardia. These experiments indicate that<jats:sc>l<\/jats:sc>\u2010NAME\u2010induced hypertension is not relying only on ANS. Also,<jats:sc>l<\/jats:sc>\u2010NAME\u2010induced tachycardia in rabbits treated with atropine plus hexamethonium suggests other humoral mechanisms that may be involved in the<jats:sc>l<\/jats:sc>\u2010NAME induced chronotropic response.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2006.00405.x","type":"journal-article","created":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T11:55:51Z","timestamp":1143460551000},"page":"239-245","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of acute inhibition of nitric oxide synthesis by<scp>l<\/scp>\u2010NAME on cardiovascular responses following peripheral autonomic blockade in rabbits"],"prefix":"10.1111","volume":"20","author":[{"given":"Ehab S.","family":"Eldesoky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,27]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada S.","year":"1991","journal-title":"Pharmacol. 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