{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:29:23Z","timestamp":1761596963726},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T00:00:00Z","timestamp":1147824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of <jats:italic>\u03b1<\/jats:italic>\u2010ketoglutarate (<jats:italic>\u03b1<\/jats:italic>\u2010KG) during <jats:italic>N<\/jats:italic>\u2010nitrosodiethylamine (NDEA)\u2010induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA\u2003+\u2003CCl<jats:sub>4<\/jats:sub>\u2010treated animals when compared with control animals. Administration of <jats:italic>\u03b1<\/jats:italic>\u2010KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA\u2003+\u2003CCl<jats:sub>4<\/jats:sub>\u2010treated animals when compared with control animals. <jats:italic>\u03b1<\/jats:italic>\u2010KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione\u2010S\u2010transferase were found to be significantly higher in liver tissue of NDEA\u2003+\u2003CCl<jats:sub>4<\/jats:sub>\u2010treated animals when compared with control animals. <jats:italic>\u03b1<\/jats:italic>\u2010KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that <jats:italic>\u03b1<\/jats:italic>\u2010KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant\u2013antioxidant imbalance during hepatocarcinogenesis.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2006.00422.x","type":"journal-article","created":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T16:18:34Z","timestamp":1147882714000},"page":"477-480","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolic normalization of <i>\u03b1<\/i>\u2010ketoglutarate against <i>N<\/i>\u2010nitrosodiethylamine\u2010induced hepatocarcinogenesis in rats"],"prefix":"10.1111","volume":"20","author":[{"given":"K.B.","family":"Dakshayani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Manivasagam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mohamed Essa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,17]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1236","volume-title":"Diseases of the liver","author":"Okuda K.","year":"1993"},{"key":"e_1_2_6_3_2","volume-title":"Globocan. 2000. 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