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Ethanol (7.2% v\/v) was given to rats by a liquid diet for 15\u2003days. <jats:italic>Hypericum perforatum<\/jats:italic> extract (HPE) (25\u2013200\u2003mg\/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After second, fourth and sixth hour of ethanol withdrawal, rats were observed for 5\u2003min, and withdrawal signs that included locomotor hyperactivity, stereotyped behavior and tremors were recorded or rated. A second series of injections was given at 6\u2003h after the first one, and subjects were then tested for audiogenic seizures. HPE (25\u2013200\u2003mg\/kg) produced some dose\u2010dependent and significant inhibitory effects on locomotor hyperactivity at second and sixth hour of ethanol withdrawal. In addition, it significantly reduced the number of stereotyped behaviors at the same dose range. HPE (50 and 100\u2003mg\/kg) produced some significant inhibitory effects on tremor and audiogenic seizures during withdrawal period. These results suggest that HPE has some beneficial effects on ethanol withdrawal syndrome in rats.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2006.00432.x","type":"journal-article","created":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T16:09:56Z","timestamp":1151078996000},"page":"481-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Attenuation of ethanol withdrawal syndrome by extract of <i>Hypericum perforatum<\/i> in Wistar rats"],"prefix":"10.1111","volume":"20","author":[{"given":"Ilke","family":"Coskun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tayfun Uzbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilgun","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979531"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979532"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(99)00005-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7052.253"},{"key":"e_1_2_6_6_2","first-page":"241","article-title":"St John's wort for depression \u2013 an overview and meta\u2010analysis of randomized clinical trials","volume":"313","author":"Melchart D.","year":"1996","journal-title":"Br. 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