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Bilateral carotid artery occlusion of 17\u2003min followed by reperfusion for 24\u2003h was employed in present study to produce ischemia\u2010 and reperfusion\u2010induced cerebral injury in mice. Cerebral infarct size was measured using triphenyltetrazolium chloride staining. Memory was evaluated using Morris water\u2010maze test. Rota\u2010rod test was employed to assess motor incoordination. Bilateral carotid artery occlusion followed by reperfusion produced cerebral infarction and impaired memory and motor coordination. Three preceding episodes of bilateral carotid artery occlusion for 1\u2003min and reperfusion of 1\u2003min (ischemic preconditioning) prevented markedly ischemia\u2013reperfusion\u2010induced cerebral injury measured in terms of infarct size, loss of memory and motor coordination. Sodium cromoglycate (10\u2003mg\/kg, i.p.), a mast cell stabilizer attenuated the neuroprotective effect of ischemic preconditioning. It is concluded that neuroprotective effect of ischemic preconditioning may be due to the degranulation of mast cells.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2008.00567.x","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T10:19:41Z","timestamp":1205489981000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Implication of mast cell degranulation in ischemic preconditioning\u2010induced prevention of cerebral injury"],"prefix":"10.1111","volume":"22","author":[{"given":"Ashish K","family":"Rehni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Bhateja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amteshwar S.","family":"Jaggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0022-3565(24)37225-8","article-title":"Synthetic combined superoxide dismutase\/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury","volume":"284","author":"Baker K.","year":"1998","journal-title":"J.\u00a0Pharmacol. 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