{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T23:41:47Z","timestamp":1741131707977,"version":"3.38.0"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:00:00Z","timestamp":1302220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Earlier studies have implicated reactive oxygen species and transitional metals in the pathogenesis of gastric lesions. In this study, we have evaluated the effect of 2,3\u2010dimercaptopropanol (DMP), a thiol compound and metal chelator, on chemically induced gastroduodenal ulcers in rats. Acid secretion studies were undertaken using pylorus\u2010ligated rats pretreated with DMP (3\u2013100\u2003mg\/kg, i.p.). The effect of orally administered DMP on cysteamine\u2010induced duodenal ulcers and ethanol\u2010induced gastric ulcers was also tested. The level of nonprotein sulfhydryls (NP\u2010SH) and gastric wall mucus was measured in the glandular stomach of rats treated with ethanol. None of the dose of DMP affected the volume or acidity of gastric secretion. Low doses of DMP (3 and 10\u2003mg\/kg) significantly reduced cysteamine\u2010induced duodenal ulcers, whereas the high doses (30 and 100\u2003mg\/kg) were ineffective in this model. All the doses of DMP significantly and dose dependently attenuated ethanol\u2010induced gastric lesions. The adverse effects of ethanol on gastric wall mucus and NP\u2010SH were significantly and dose dependently reversed by DMP. In conclusion, the protective effects of DMP appear to be independent of gastric acid secretion and may be associated with counteracting the oxidative stress by replenishing glutathione and reducing the pool of transition metals.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.00941.x","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:17:37Z","timestamp":1302268657000},"page":"402-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["2,3\u2010Dimercaptopropanol, a thiol chelator, alleviates gastroduodenal ulcers in rats"],"prefix":"10.1111","volume":"26","author":[{"given":"Meshal","family":"Al Moutaery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannan","family":"Al Rayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramaiz","family":"Al Swailam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Elfaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haseeb Ahmad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Saleh","family":"Alhomida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Arshaduddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b975b8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2009.3.4.252"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04058.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.04.014"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00286.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-008-0101-0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/155335060501200306"},{"key":"e_1_2_6_9_2","first-page":"39","article-title":"Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury","volume":"53","author":"Kwiecie\u0144 S.","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-36"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-008-8205-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111145"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.78.435"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90276-9"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7280691"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i38.5121"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90257.2008"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.04.016"},{"key":"e_1_2_6_19_2","first-page":"26","article-title":"Arsenic and lead induced free radical generation and their reversibility following chelation","volume":"53","author":"Flora S.J.","year":"2007","journal-title":"Cell. Mol. Biol."},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659609013836"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01630484"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780050404"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-192304000-00006"},{"key":"e_1_2_6_24_2","first-page":"273","article-title":"Animal model of human disease. Cysteamine induced acute and chronic duodenal ulcer in the rat","volume":"93","author":"Szabo S.","year":"1978","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2001.9193"},{"key":"e_1_2_6_26_2","first-page":"885","article-title":"Gastroprotective effects of mornifulmate, an esterified anti\u2010inflammatory drug","volume":"34","author":"Schiantarelli P.","year":"1984","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_6_27_2","first-page":"116","article-title":"A method for the quantitative estimation of gastric barrier mucus","volume":"242","author":"Corne S.J.","year":"1974","journal-title":"J. Physiol."},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000138721"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90410-E"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.3748\/wjg.v12.i36.5798","article-title":"Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats","volume":"13","author":"Tariq M.","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-006-1524-6"},{"key":"e_1_2_6_33_2","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0022-3565(25)22534-4","article-title":"YMO22 {(R)\u20101\u2010(2,3\u2010dihydro\u20101\u2010(2\u2010methyl\u2010phenacyl)\u20102\u2010oxo\u20105\u2010phenyl\u20101H\u201014\u2010benzodiazepin\u20103\u2010yl)\u20103\u2010(3\u2010methylphenyl)\u2010urea}, a potent and selective gastrin\/cholecystokinin\u2010B receptor antagonist, prevents gastric duodenal lesions in rats","volume":"270","author":"Nishida A.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0022-3565(25)09542-4","article-title":"RP 73870, a gastrin\/cholecystokinin\u2010B receptor antagonist with potent anti\u2010ulcer activity in the rat","volume":"273","author":"Pendley C.E.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0022-5347(25)00305-2","article-title":"Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats","volume":"241","author":"Tariq M.","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_36_2","first-page":"151","article-title":"Low susceptibility of stress ulcer in diabetic rats: role of cholinergic gastric motility","volume":"41","author":"Hung C.R.","year":"1998","journal-title":"Clin. J. Physiol."},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00020.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90002-7"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.57.63"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309333"},{"key":"e_1_2_6_41_2","first-page":"69","article-title":"Distinction between antiulcer effect and cytoprotection","volume":"101","author":"Robert A.","year":"1984","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.38.337"},{"key":"e_1_2_6_43_2","first-page":"247","article-title":"The role of gastric and duodenal pH in the cysteamine\u2010induced duodenal ulcer in the rat","volume":"73","author":"Kusterer K.","year":"1989","journal-title":"Acta Physiol. Hung."},{"key":"e_1_2_6_44_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0022-5347(25)00398-2","article-title":"Effect of dopamine\u2010related drugs on duodenal ulcer induced by cysteamine or propionitrile: prevention and aggravation may not be mediated by gastrointestinal secretory changes in the rat","volume":"240","author":"Gallagher G.","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0022-3565(25)20869-2","article-title":"Activity of selective dopamine DA1 and DA2 agonists and antagonists on experimental gastric lesions and gastric acid secretion","volume":"251","author":"Glavin G.B.","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.014s1033.x"},{"key":"e_1_2_6_47_2","first-page":"11","article-title":"Role of oxygen\u2010derived free radicals in the mechanism of cysteamine\u2010induced duodenal ulcer in rats","volume":"93","author":"Chen S.H.","year":"1994","journal-title":"J. Formos. Med. Assoc."},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.32725\/jab.2007.011"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018332618512"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2001.23.7.662125"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(98)90023-8"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(85)80180-3"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509089275"},{"key":"e_1_2_6_54_2","first-page":"1191","article-title":"The gastric mucosal epithelial barrier: role of mucus and fibrin","volume":"20","author":"Allen A.","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90629-3"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50106a010"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1159\/000139015"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05021.x"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200718"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00757-8"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088233"},{"key":"e_1_2_6_62_2","first-page":"87","article-title":"Gastric anti\u2010ulcer and cytoprotective effect of vitamin E in rats","volume":"60","author":"Tariq M.","year":"1988","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.42.167"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90010-8"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005652815921"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780124"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1472-8206.2011.00941.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1472-8206.2011.00941.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T23:27:52Z","timestamp":1741130872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1472-8206.2011.00941.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,8]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1472-8206.2011.00941.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1472-8206.2011.00941.x","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"type":"print","value":"0767-3981"},{"type":"electronic","value":"1472-8206"}],"subject":[],"published":{"date-parts":[[2011,4,8]]},"assertion":[{"value":"2011-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}