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Nevertheless, it still remains to be found the mechanism by which vitamin A induces cognitive decline. Based on the fact that vitamin A at clinical doses is a potent pro\u2010oxidant agent to the central nervous system, we performed the present work to analyze whether a cotreatment with L\u2010NAME at 30\u2003mg\/kg (four times a week) was able to prevent (or minimize) the biochemical and\/or behavioral disturbances resulting from a 28\u2010day daily supplementation with retinol palmitate at doses from 1000 to 9000\u2003IU\/kg\/day. Then, we investigated mitochondrial function, redox parameters, and the levels of proteins potentially involved in neurodegenerative events, as for instance \u03b1\u2010synuclein and receptor for advanced glycation endproducts. Besides, monoamine oxidase enzyme activity was quantified in this work. We observed that L\u2010NAME cotreatment was not completely effective in preventing the redox disturbances induced by vitamin A supplementation. Moreover, L\u2010NAME cotreatment did not affect the behavioral deficits elicited by vitamin A supplementation. We conclude that other parameters rather than NO levels or its derivatives, as for example ONOO<jats:sup>\u2212<\/jats:sup>, take a more important role in mediating the negative effects triggered by vitamin A supplementation.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.00943.x","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T03:00:37Z","timestamp":1303873237000},"page":"513-529","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["L\u2010NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation"],"prefix":"10.1111","volume":"26","author":[{"given":"Marcos Roberto","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Fagundes","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Eduardo","family":"Schnorr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Cl\u00e1udio Fonseca","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02935566"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.9.2907S"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.6.1152"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3181\/0706-MR-158"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90013-Y"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(91)90057-Z"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2000.0121"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.057547"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.842"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.07.002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.07.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.07.008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9438-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.020"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.02.006"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.10.002"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb800279q"},{"key":"e_1_2_6_19_2","first-page":"2069","article-title":"Pharmacology of 13\u2010cis\u2010retinoic acid in humans","volume":"42","author":"Kerr I.G.","year":"1982","journal-title":"Cancer Res."},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542225"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1998.tb04388.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.01.003"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.pto_359.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.07.016"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb05809.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)90055-8"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0146"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.02.009"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69497-9"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0976-5"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3600001"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn983"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.01.002"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1883"},{"key":"e_1_2_6_36_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/22.8.1033","article-title":"Somepossible roles for vitamin A in membranes: micelle formation and electron transfer","volume":"22","author":"Lucy J.A.","year":"1969","journal-title":"Am. 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