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As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant\u2010like action of ripIII. Following intraperitoneal administration of ripIII at doses of 25 and 50\u2003mg\/kg, there were decreases in the immobility time in the FST and tail suspension test without accompanying changes in ambulation (data not shown). The pretreatment of mice with sulpiride (50\u2003mg\/kg, i.p.), prazosin (1\u2003mg\/kg, i.p.), yohimbine (1\u2003mg\/kg, i.p.), and <jats:italic>p<\/jats:italic>\u2010chlorophenylalanine (PCPA, 100\u2003mg\/kg, i.p. for, four consecutive days) significantly prevented the anti\u2010immobility effect of ripIII in the FST. On the other hand, the anti\u2010immobility effect of ripIII (50\u2003mg\/kg, v.o.) was not altered by pretreatment of mice with SCH23390 (15\u2003\u03bcg\/kg, i.p.) Furthermore, ripIII potentiated the sleeping latency and sleeping time of the pentobarbital\u2010induced sleeping time test and also potentiated apomorphine (16\u2003mg\/kg, i.p.)\u2010induced hypothermia in mice. In conclusion, the present study provides evidence that the antidepressant\u2010like effect of ripIII is dependent on its interaction with the serotonergic, noradrenergic (\u03b1<jats:sub>1<\/jats:sub>\u2010 and \u03b1<jats:sub>2<\/jats:sub>\u2010 receptors), and dopaminergic (dopamine D<jats:sub>2<\/jats:sub> receptors) systems.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.00968.x","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T02:47:11Z","timestamp":1311821231000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the antidepressant\u2010like action of riparin III obtained from <i>Aniba riparia<\/i> (Nees) Mez (Lauraceae) in mice"],"prefix":"10.1111","volume":"27","author":[{"given":"Carla Thiciane Vasconcelos","family":"Melo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyne Mara Rodrigues","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brinell Arcanjo","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Porto Leite","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Freire","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Lima","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gersilene Valente","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Maria","family":"Barbosa\u2010Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley Juan","family":"Chavez Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Maria","family":"de Fran\u00e7a Fonteles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silv\u00e2nia Maria Mendes","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca Cl\u00e9a Floren\u00e7o","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,27]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"36","article-title":"Prevalence of mental disorders in Europe: results from the European Study of Epidemiology of Mental Disorders (ESEMeD) project","volume":"110","author":"Bernet S.","year":"2004","journal-title":"Acta Psychiatr. 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