{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:48:01Z","timestamp":1792604881169,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:00:00Z","timestamp":1312329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The anti\u2010ulcerogenic potentials of low doses of rutin and cimetidine in ethanol\u2010, acetic acid\u2010, and stress\u2010induced ulcers in rats have been evaluated and compared in this study. In each model, male Wistar rats were randomly divided into six groups (I\u2013VI). Groups II\u2013VI were administered 1\u2003mL\/100\u2003g ethanol orally, 0.05\u2003mL of 20% acetic acid submucosally or kept in a cold chamber for 6\u2003h to induce ulcer in the ethanol\u2010, acetic acid\u2010, and stress\u2010induced ulceration model, respectively. Thereafter, group III was post\u2010treated with 300\u2003mg\/kg cimetidine and groups IV\u2013VI with 20, 40, and 80\u2003mg\/kg rutin, respectively, while the control (group I) received distilled water in Tween 20. One hour after post\u2010treatment, all groups were killed and the gastric ulcer index was calculated. Malondialdehyde (MDA) level, vitamin C content, and glutathione peroxidase (GPx) activity were evaluated in the gastric mucosa of animals. Post\u2010treatment with rutin significantly reduced ulcerogen\u2010induced gastric damage in all models. This effect was significant at all dose levels compared with the ulcer\u2010induced groups. Rutin significantly reduced the MDA levels but increased the vitamin C content and GPx activity. Ulcer index and MDA level were highest in the ethanol\u2010induced ulcer model while vitamin C content and GPx activity were lowest in the stress\u2010induced ulcer model. The study showed that all three models of ulceration appeared to be linked to oxidative stress and also ascribed significant anti\u2010ulcerogenic potential to rutin especially at lower doses of 20\u201380\u2003mg\/kg.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.00972.x","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T22:25:25Z","timestamp":1312410325000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparative gastroprotective effect of post\u2010treatment with low doses of rutin and cimetidine in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Mary Tolulope","family":"Olaleye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afolabi Clement","family":"Akinmoladun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.3.1740232"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb00885.x"},{"key":"e_1_2_6_4_2","first-page":"1","article-title":"Peptic ulcer diseases","volume":"2","author":"Mark F.","year":"2007","journal-title":"Gastroenterology"},{"key":"e_1_2_6_5_2","first-page":"265","article-title":"A radical review of the stomach: the role of oxygen\u2010derived free radicals and anti\u2010oxidants in gastroduodenal disease","volume":"7","author":"Pull P.S.","year":"1995","journal-title":"Eur. 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