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In recent years, the molecular cloning of the diuretic\u2010sensitive sodium transporters at distal convoluted tubule has improved our understanding of the cellular mechanisms of action of each class of diuretics. Diuretics are tools of considerable therapeutic importance. First, they effectively reduce blood pressure. Loop and thiazide diuretics are secreted from the proximal tubule via the organic anion transporter\u20101 and exert their diuretic action by binding to the Na\n                    <jats:sup>+<\/jats:sup>\n                    \u2010K\n                    <jats:sup>+<\/jats:sup>\n                    \u20102Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    co\u2010transporter type 2 in the thick ascending limb and the Na\n                    <jats:sup>+<\/jats:sup>\n                    \u2010 Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    co\u2010transporter in the distal convoluted tubule, respectively. Recent studies in animal models suggest that abundance of these ion transporters is affected by long\u2010term diuretic administration. The WHO\/ISH guidelines point out that diuretics enhance the efficacy of antihypertensive drugs and will most often be a component of combination therapy.\n                  <\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.01012.x","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T04:41:10Z","timestamp":1323232870000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The target\u2010specific transporter and current status of diuretics as antihypertensive"],"prefix":"10.1111","volume":"26","author":[{"given":"Syed Salman","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin Kumar","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avnesh Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambhu Charan","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118834"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3565(24)38896-2","article-title":"Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter","volume":"295","author":"Uwai Y.","year":"2000","journal-title":"J. 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