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This study was designed to investigate the effects of melatonin (MEL) and erythropoietin (EPO), which is a known anti\u2010inflammatory and antiapoptotic agent, in dinitrobenzene sulfonic acid (DNBS)\u2013induced colitis in pinealectomized (Px) rats. In microscopically results, epithelial and goblet cell loss, absence of crypts, and increased colonic caspase\u20103 activity were observed in the DNBS group. Also, in flow cytometric analysis, the percentage of CD4+ T cells was highest in the DNBS group. Treatment with MEL or EPO had a curative effect on DNBS\u2010induced colitis. The MEL\u2003+\u2003EPO groups showed significantly greater improvement when compared with the other treatment groups. Our results indicate that the combination of EPO and MEL may exert more beneficial effects than either agent used alone.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.01016.x","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T09:17:42Z","timestamp":1323681462000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of endogen\u2010exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid\u2013induced colitis"],"prefix":"10.1111","volume":"27","author":[{"given":"Seda","family":"Tasdemir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Parlakpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigar","family":"Vardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Acet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(00)00238-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:29:1-3:055"},{"key":"e_1_2_6_4_2","first-page":"156","article-title":"The immune system in inflammatory bowel disease","volume":"60","author":"Fiocchi C.","year":"1997","journal-title":"Acta Gastroenterol. 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