{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:45:26Z","timestamp":1789181126583,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Croton zehntneri,<\/jats:italic> a plant native to northeastern Brazil, is widely used in folk medicine to treat gastrointestinal problems and has rich essential oil content. The effects of the essential oil of <jats:italic>Croton zehntneri<\/jats:italic> (EOCZ) and its main constituent anethole on several models of gastric lesions were studied in mice and rats. Oral treatment with EOCZ and anethole, both at doses of 30\u2013300\u2003mg\/kg, caused similar and dose\u2010dependent gastroprotection against ethanol\u2010 and indomethacin\u2010induced gastric damage, but did not change cold\u2010restraint stress\u2010induced ulcers in rats. Furthermore, EOCZ and anethole (both at 30 and 300\u2003mg\/kg) similarly and significantly increased the mucus production by the gastric mucosa, measured by Alcian blue binding, in ethanol\u2010induced ulcer model. However, at the same doses, neither EOCZ nor anethole promoted significant alteration in gastric production of non\u2010protein sulfhydryl groups. In pylorus\u2010ligated model, neither EOCZ nor anethole (both at 30 and 300\u2003mg\/kg) had a significant effect on the volume of gastric juice, pH, or total acidity. The results of this study show for the first time that EOCZ possesses a gastroprotective potential, an effect mostly attributed to the action of anethole. This activity is related predominantly to the ability of EOCZ and anethole to enhance the production of gastric wall mucus, an important gastroprotective factor. Furthermore, they suggest that EOCZ has potential therapeutic application for the treatment of gastric ulcers.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2011.01021.x","type":"journal-article","created":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T05:18:23Z","timestamp":1325567903000},"page":"288-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Essential oil of <i>Croton zehntneri<\/i> and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer"],"prefix":"10.1111","volume":"27","author":[{"given":"Andrelina N.","family":"Coelho\u2010de\u2010Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Lahlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o E.F.","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.M.","family":"Yum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aricl\u00e9cio C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herm\u00f3genes D.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia R.","family":"Celed\u00f4nio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roney G.F.","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria P.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia F.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline A.C.","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 H.","family":"Leal\u2010Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,3]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"445","article-title":"\u00d3leos essenciais de canelas silvestres regionais","volume":"29","author":"Craveiro A.A.","year":"1977","journal-title":"Cienc. 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