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Four years before, she underwent a mitral valve replacement after the diagnosis of mitral regurgitation during benfluorex treatment (150\u2003mg\/day). This drug was reintroduced postoperatively. She presented with exercise and sometimes resting dyspnoea. The bioprosthesis and aortic valves exhibited similar histopathological lesions. Thickening and plaque deposits made by smooth muscle alpha actin\u2010 and vimentin\u2010positive cells in a glycosaminoglycan matrix were observed. The study discusses the putative contribution of circulating progenitor cells activated by 5\u2010HT<jats:sub>2B<\/jats:sub> receptor agonists in the development of drug\u2010induced heart disease.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01027.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T17:08:59Z","timestamp":1328807339000},"page":"215-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy"],"prefix":"10.1111","volume":"26","author":[{"given":"Estelle","family":"Ayme\u2010Dietrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dallemand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Monassier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,9]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-4455-4"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60252-X"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.6.1223"},{"key":"e_1_2_2_5_2","first-page":"626","article-title":"Organ culture as a tool to identify early mechanisms of serotonergic valve disease","volume":"19","author":"Barzilla J.E.","year":"2010","journal-title":"J. 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