{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:20:51Z","timestamp":1792844451545,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T00:00:00Z","timestamp":1332892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study was designed to evaluate antidepressant\u2010like activity of gallic acid in Swiss young male albino mice subjected to unpredictable chronic mild stress and to explore the possible underlying mechanisms for this activity. Gallic acid (5, 10, 20\u2003mg\/kg, i.p.) and fluoxetine (10\u2003mg\/kg, i.p.) per se were administered daily to unstressed mice and other groups of mice subjected to unpredictable mild stress, 30\u2003min after the injection for 21\u2003successive days. The antidepressant\u2010like activity was evaluated using forced swim test (FST) and sucrose preference test. Stress significantly increased immobility period of mice in FST. Gallic acid (10 and 20\u2003mg\/kg, i.p.) and fluoxetine significantly decreased immobility period of unstressed and stressed mice in FST and prevented the stress\u2010induced decrease in sucrose preference, indicating significant antidepressant\u2010like activity. There was no significant effect on locomotor activity of the mice by the drugs. Gallic acid (10 and 20\u2003mg\/kg, i.p.) significantly decreased Monoamine oxidase\u2010A (MAO\u2010A) activity, malondialdehyde levels, and catalase activity in unstressed mice; and significantly prevented the stress\u2010induced decrease in reduced glutathione and catalase activity; and also significantly prevented stress\u2010induced increase in MAO\u2010A activity, malondialdehyde levels, plasma nitrite, and corticosterone levels. Thus, gallic acid showed antidepressant\u2010like activity in unstressed and stressed mice probably due to its antioxidant activity and through inhibition of MAO\u2010A activity and decrease in plasma nitrite levels. In addition, gallic acid also showed antidepressant\u2010like activity in stressed mice probably through decrease in plasma corticosterone levels.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01040.x","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T04:46:17Z","timestamp":1333082777000},"page":"409-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Antidepressant\u2010like activity of gallic acid in mice subjected to unpredictable chronic mild stress"],"prefix":"10.1111","volume":"27","author":[{"given":"Ritu","family":"Chhillar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,28]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"7","article-title":"Pathophysiology of depression and mechanisms of treatment, dialogues","volume":"4","author":"Bondy B.","year":"2002","journal-title":"Clin. Neurosci."},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.038"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35072566"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.6.837"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023362023"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050456"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187257"},{"key":"e_1_2_8_9_2","first-page":"185","article-title":"Implication of the hypothalamic\u2013pituitary\u2013adrenal axis in the physiopathology of depression","volume":"29","author":"Barden N.","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)00204-I"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00199-3"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1077(199607)11:4<309::AID-HUP775>3.0.CO;2-B"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520310103"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.09.077"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16064428"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.03.021"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15096244"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903029365"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.02.004"},{"key":"e_1_2_8_20_2","article-title":"Protective effects of olive oil phenolics and gallic acid on hydrogen peroxide\u2010induced apoptosis","author":"Erol\u2010Dayi O.","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.10.010"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0635-7"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00022-9"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.08.059"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2094-2"},{"key":"e_1_2_8_26_2","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt R.D.","year":"1977","journal-title":"Arch. Int. Pharmacodyn."},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90306-O"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac197951102157"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90369-5"},{"key":"e_1_2_8_31_2","first-page":"692","volume-title":"Methods in Enzymology, XVIIB","author":"Charles M.","year":"1977"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.11.010"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087097"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00332-0"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103573"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0326-2"},{"key":"e_1_2_8_37_2","first-page":"535","volume-title":"Pharmacology","author":"Rang H.P.","year":"2003"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1472-8206.2012.01040.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1472-8206.2012.01040.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:01:38Z","timestamp":1696320098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1472-8206.2012.01040.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,28]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/j.1472-8206.2012.01040.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1472-8206.2012.01040.x","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,28]]},"assertion":[{"value":"2012-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}