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In the novel object recognition test, <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> (10\u00a0mg\/kg\/day for 10\u00a0days)\u2010induced cognitive deficits in mice were not improved by a single administration of <jats:styled-content style=\"fixed-case\">CDPPB<\/jats:styled-content> (10\u00a0mg\/kg\/day). However, <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> (10\u00a0mg\/kg\/day for 10\u00a0days)\u2010induced cognitive deficits in mice were significantly improved by subsequent subchronic (14\u00a0days) administration of <jats:styled-content style=\"fixed-case\">CDPPB<\/jats:styled-content> (10\u00a0mg\/kg\/day), but not of <jats:styled-content style=\"fixed-case\">CDPPB<\/jats:styled-content> (1.0\u00a0mg\/kg\/day). This study suggests that <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content>\u2010induced cognitive deficits in mice are improved by subsequent subchronic administration of <jats:styled-content style=\"fixed-case\">CDPPB<\/jats:styled-content>. Therefore, m<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lu<jats:sub>5<\/jats:sub> <jats:styled-content style=\"fixed-case\">PAM<\/jats:styled-content>s would be potential therapeutic drugs for cognitive deficits in schizophrenia.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01045.x","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T12:27:32Z","timestamp":1335961652000},"page":"483-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator <scp>CDPPB<\/scp> on phencyclidine\u2010induced cognitive deficits in mice"],"prefix":"10.1111","volume":"27","author":[{"given":"Mao","family":"Horio","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1\u20108\u20101 Inohana Chiba 260\u20108670 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1\u20108\u20101 Inohana Chiba 260\u20108670 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1\u20108\u20101 Inohana Chiba 260\u20108670 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.3.321"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035458"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1709-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.06.023"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.07.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.10.1301"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950240016004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673229609017192"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/hrp.7.3.125","article-title":"NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders","volume":"7","author":"Krystal J.H.","year":"1999","journal-title":"Harv. 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