{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:21:24Z","timestamp":1790976084821,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to examine the prognostic value of serum <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> biomarkers in hypertensive patients with no history of cardiovascular events. In a community\u2010based cohort study of 125 hypertensive patients free of cardiovascular events, we collected clinical data and blood samples to assess serum levels of amino\u2010terminal propeptide of type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> procollagen (<jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content>), matrix metalloproteinase type 1(<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>1) and tissue inhibitor of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s type 1(<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>1). Left ventricular hypertrophy (<jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>) was assessed using the <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> Cornell product. Patients were followed up for death or cardiovascular hospitalisation. We used Cox regression models to assess the prognostic value of <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> biomarkers. The sample included 60.8% women; the mean (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age was 62.9 (\u00b111.4) years. Patients were followed up for a median of 5.5\u00a0years, during which 23 events (five deaths) occurred. <jats:styled-content style=\"fixed-case\">PIIINP<\/jats:styled-content> (3.2\u00a0\u00b1\u00a01.0 vs. 2.6\u00a0\u00b1\u00a00.8\u00a0\u03bcg\/L, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>1 (886\u00a0\u00b1\u00a0168 vs. 751\u00a0\u00b1\u00a0202\u00a0\u03bcg\/L, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) levels were higher in the presence of <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> than with no <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>. Basal <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>1 serum levels were significantly associated with <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> events (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>1: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.06; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [1.02\u20131.09]). Adjusting for confounders did not modify this result. Cardiac fibrosis, as assessed with serum <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> biomarkers, might develop early in hypertensive patients and is predictive of cardiovascular events or death.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01053.x","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T03:37:49Z","timestamp":1339385869000},"page":"572-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prognostic value of serum <scp>PIIINP<\/scp>,<scp> MMP<\/scp>1 and <scp>TIMP<\/scp>1 levels in hypertensive patients: a community\u2010based prospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Nelly","family":"Agrinier","sequence":"first","affiliation":[{"name":"INSERM CIC\u2010EC CIE6 Nancy F\u201054 000 France"},{"name":"CHU Nancy Epid\u00e9miologie et Evaluation Cliniques Nancy F\u201054 000 France"},{"name":"Universit\u00e9 de 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