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Furthermore, eugenol showed antidepressant\u2010like effect; however, the biological actions of\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010eugenol on experimental models for screening antidepressant activity are still unknown. The present study investigated a possible antidepressant\u2010like activity of\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010eugenol in the forced swimming test (\n                    <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>\n                    ) and tail suspension test (\n                    <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>\n                    ) in mice and the involvement in the monoaminergic system in this effect. In addition, a neurochemical analysis on brain monoamines of mice acutely treated with\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010eugenol was also conducted.\n                    <jats:italic>Bis<\/jats:italic>\n                    \u2010eugenol decreased the immobility time in the\n                    <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>\n                    without accompanying changes in ambulation in the open field test at 10\u00a0mg\/kg, i.p.. Nevertheless, it induced ambulation at 25 and 50\u00a0mg\/kg doses. The anti\u2010immobility effect of\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010eugenol (10 and 50\u00a0mg\/kg, i.p.) was prevented by pretreatment of mice with p\u2010chlorophenylalanine (\n                    <jats:styled-content style=\"fixed-case\">PCPA<\/jats:styled-content>\n                    , 100\u00a0mg\/kg, i.p., an inhibitor of serotonin synthesis, for four consecutive days), yohimbine (1\u00a0mg\/kg, i.p., an \u03b12\u2010adrenoceptor antagonist),\n                    <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>\n                    23390 (15\u00a0\u03bcg\/kg, s.c., a dopamine D1 receptor antagonist) and sulpiride (50\u00a0mg\/kg, i.p., a dopamine D2 receptor antagonist). Monoamines analysis using high\u2010performance liquid chromatograph revealed significant increase in the 5\u2010\n                    <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    levels in brain striatum. The present study indicates that\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010eugenol possesses antidepressant\u2010like activity in\n                    <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>\n                    by altering dopaminergic, serotonergic and noradrenergic systems function.\n                  <\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01058.x","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T11:09:44Z","timestamp":1339672184000},"page":"471-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antidepressant\u2010like effect of\n                    <i>bis<\/i>\n                    \u2010eugenol in the mice forced swimming test: evidence for the involvement of the monoaminergic system"],"prefix":"10.1111","volume":"27","author":[{"given":"Jeferson Falc\u00e3o","family":"do Amaral","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel. 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