{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:46:53Z","timestamp":1791888413911,"version":"4.3.4"},"reference-count":151,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T00:00:00Z","timestamp":1343692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010citrulline is a naturally occurring non\u2010essential amino acid, an intermediate in urea cycle and conditionally essential in intestinal pathology. It is a potent hydroxyl radical scavenger and much more effective precursor of arginine and nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) than arginine itself so exploited in therapeutics. Plasma citrulline concentration is used by clinicians to assess functional enterocyte mass in various chronic and acute small bowel pathologies like short bowel syndrome that has become an indication in clinical practice. Its supplementation is likely to be used in conditions like erectile dysfunction, sickle cell anemia, short bowel syndrome (to restore nitrogen balance), hyperlipidemia, cancer chemotherapy, hypercholestremia, in hyperoxic lung damage, urea cycle disorders, Alzheimers disease, multi\u2010infarct dementia and as an immunomodulator. Its emerging role as a biomarker in intestinal pathology and early diagnosis of Rheumatoid arthritis has spread considerable interest. Antibody detection to Anti\u2010cyclic citrullinated peptide (<jats:styled-content style=\"fixed-case\">ACCP<\/jats:styled-content>) antibodies can be recommended for early detection of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> decreasing joint damage and deformity, because these are detected well before the onset of disease manifestations of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. The test is highly specific than <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> (Rheumatoid factor), with moderate sensitivity, but much useful in differentiating <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> from other disorders. Further studies and exploration is required in these areas.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01059.x","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T16:26:09Z","timestamp":1340382369000},"page":"35-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Citrulline: pharmacological perspectives and its role as an emerging biomarker in future"],"prefix":"10.1111","volume":"27","author":[{"given":"Shilpa N.","family":"Kaore","sequence":"first","affiliation":[{"name":"Department of Pharmacology People's College of Medical Sciences Bhanpur Road Bhopal Madhya Pradesh 462037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmant S.","family":"Amane","sequence":"additional","affiliation":[{"name":"Department of Pharmacology People's College of Medical Sciences Bhanpur Road Bhopal Madhya Pradesh 462037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navinchandra M.","family":"Kaore","sequence":"additional","affiliation":[{"name":"Department of Microbiology People's College of Medical Sciences Bhanpur Road Bhopal Madhya Pradesh 462037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,31]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"420","article-title":"\u00dcber Citrullin, eine neue Aminos\u00e4ure im presssaft der Wassermelone, Citrullus vulgaris schrad","volume":"224","author":"Wada M.","year":"1930","journal-title":"Biochem. Zeit."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2007.01.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.05.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcf074"},{"issue":"6","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1605S","DOI":"10.1093\/jn\/134.6.1605S","article-title":"Clinical manifestations of inborn errors of the urea cycle and related metabolic disorders during childhood","volume":"134","author":"Endo F.","year":"2004","journal-title":"J. Nutr."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2006.00275.x"},{"key":"e_1_2_9_8_1","first-page":"160","article-title":"Plasma citrulline concentration \u2013 a reliable noninvasive marker of functional enterocyte mass","volume":"149","author":"Oliverius M.","year":"2010","journal-title":"Cas. Lek. Cesk."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2007.25765"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1017\/S0007114507841110","article-title":"Dose\u2010ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study","volume":"99","author":"Moinard C.","year":"2007","journal-title":"Br. J. Nutr."},{"key":"e_1_2_9_11_1","first-page":"363","article-title":"Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results","volume":"93","author":"Waugh W.H.","year":"2001","journal-title":"J. Natl Med. Assoc."},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"18060","DOI":"10.1093\/jn\/136.7.1806","article-title":"Citrulline is an effective arginine precursor in enterally fed neonatal piglets","volume":"136","author":"Urschel K.L.","year":"2006","journal-title":"J. Nutr."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0235-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.5.H2192"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199708000-00007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04057.x"},{"key":"e_1_2_9_17_1","first-page":"895","article-title":"Arginine synthesis from citrulline in perivascular nerves of cerebral artery","volume":"273","author":"Chen F.Y.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2007.07.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02990.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x03vm474oa"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711450769936X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.12.001"},{"key":"e_1_2_9_24_1","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada S.","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4651"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114081"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2006.04.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328332f99d"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199408000-00011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1616S"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2842S"},{"key":"e_1_2_9_32_1","first-page":"353","article-title":"Inhibition of cerebral neurogenic vasodilation by L\u2010glutamine and nitric oxide synthase inhibitors and its reversal by L\u2010citrulline","volume":"276","author":"Lee T.J.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1621S"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328333c27f"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070451"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1096\/fasebj.22.1_supplement.466.6","article-title":"Effect of citrulline on cultured macrophages from Zucker Diabetic Fatty (ZDF) rats","volume":"22","author":"Bonhomme S.","year":"2008","journal-title":"FASEB J."},{"issue":"10","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"2743S","DOI":"10.1093\/jn\/134.10.2743S","article-title":"Enzymes of arginine metabolism","volume":"134","author":"Morris S.M.","year":"2004","journal-title":"J. Nutr."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109771"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819986da"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2114\/jpa2.30.41"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.03.093"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-0467-1"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03168218"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01192-5"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.600"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.4.714"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00002.2006"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.5.1047"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115987"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.05.005"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.03.002"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.5.875"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.08.024"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.1.193"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108319807"},{"key":"e_1_2_9_56_1","first-page":"331","article-title":"Glutamine: a conditionally essential nutrient or another nutritional puzzle","volume":"50","author":"Mobrahan S.","year":"1992","journal-title":"Nutr. Rev."},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.04.024"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5713"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst025404s"},{"key":"e_1_2_9_60_1","first-page":"65","article-title":"The interactions of glutamine and arginine in various tissues of cholesterol\u2010fed rats: pharmacological and therapeutical implications in hypercholesterolemia","volume":"2","author":"Abdulrahim A.\u2010J.","year":"2005","journal-title":"University of Sharjah J Pure Appl Sci."},{"key":"e_1_2_9_61_1","first-page":"II1","article-title":"Oral citrulline effectively elevates plasma arginine levels for 24\u00a0hours in normal volunteers","volume":"106","author":"Kuhn K.P.","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_9_62_1","unstructured":"KuhnK.P. HarrisP.A. CunninghamG.R. RobbinsI.M. SummarM.L. ChristmanB.W..Oral citrulline effectively elevates plasma arginine levels for 24\u00a0h in normal volunteers. Circulation AHA Scientific Sessions. (2006) abstract 1692 p. II\u20101339."},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.12.2680"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2004.09.003"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00142-0"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00803.x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.3.342"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01380-8"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00553-7"},{"key":"e_1_2_9_70_1","first-page":"612","article-title":"Effect of L\u2010arginine or L\u2010citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction","volume":"17","author":"Orozco\u2010Guti\u00e9rrez J.J.","year":"2010","journal-title":"Cardiol. J."},{"key":"e_1_2_9_71_1","first-page":"464","article-title":"The effect of L\u2010arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction","volume":"17","author":"Orea\u2010Tejeda A.","year":"2010","journal-title":"Cardiol. J."},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2010.07.006"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2010.12.004"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0283"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00806.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095794"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.03.005"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1766"},{"key":"e_1_2_9_79_1","first-page":"223","volume-title":"Cardiovascular significance of endothelium\u2010derived vasoactive factors","author":"Pieper G.M.","year":"1991"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90256-O"},{"key":"e_1_2_9_81_1","first-page":"V\u201067","article-title":"Dysfunction of vascular endothelium in diabetes mellitus","volume":"87","author":"Cohen R.A.","year":"1993","journal-title":"Circulation"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0880245"},{"key":"e_1_2_9_83_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/bj2940113","article-title":"The activation of the arginine\u2010citrulline cycle in macrophages from the spontaneously diabetic BB rat","volume":"294","author":"Wu G.","year":"1993","journal-title":"Biochem. J."},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191207498"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000210197.02576.da"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1509-4"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.08.028"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080444"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2848S"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1681S"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1232"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607104028006423"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32834ae42b"},{"key":"e_1_2_9_94_1","first-page":"275","article-title":"Amino acid concentration in dementia of the Alzheimer type and multi\u2010infarct dementia","volume":"26","author":"Mochizuki Y.","year":"1996","journal-title":"Ann. Clin. Lab. Sci."},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2716"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90155-4"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050016"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0760-1"},{"key":"e_1_2_9_99_1","first-page":"325","article-title":"The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease","volume":"18","author":"Seyidova D.","year":"2004","journal-title":"In Vivo."},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9066-5"},{"key":"e_1_2_9_101_1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1152\/ajplegacy.1964.207.6.1242","article-title":"Effects of exercise and administration of aspartic acid on blood ammonia in the rat","volume":"207","author":"Barnes R.H.","year":"1964","journal-title":"Am. J. Physiol."},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00999929"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.57.246"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1000"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.36.4.282"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y97-029"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.11.015"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.068"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3181cb28e0"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111837"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03123-4"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcd005"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760903071664"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00398.2005"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.06.005"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111414024"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.04.005"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042317"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.02.003"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.02.005"},{"key":"e_1_2_9_121_1","first-page":"513","article-title":"Circulating citrulline levels: a biomarker for intestinal functionality assessment","volume":"69","author":"Crenn P.","year":"2011","journal-title":"Ann. Biol. Clin. (Paris)."},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32829fb38d"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.04.004"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20227"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00170-7"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1159\/000170888"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2172-x"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar75"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.049403"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1316"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar95"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.034"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.2741\/1506"},{"key":"e_1_2_9_134_1","first-page":"36","article-title":"Determination of antibodies against cyclic citrullinated peptide in rheumatoid arthritis","volume":"6","author":"Kobylianskii A.G.","year":"2011","journal-title":"Klin. Lab. Diagn."},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5575"},{"key":"e_1_2_9_136_1","first-page":"99","article-title":"The specificity of anti\u2010cyclic citrullinated peptide antibodies in the diagnosis of rheumatoid arthritis from a large cohort study in the Chinese","volume":"50","author":"Li T.","year":"2011","journal-title":"Zhonghua. Nei. Ke. Za. Zhi."},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rhu.0000230483.66042.28"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8022-5"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397052954208"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400240041006"},{"key":"e_1_2_9_141_1","first-page":"231","article-title":"Anti\u2010CCP antibodies, rheumatoid factors and anti\u2010keratin antibodies: clinical value in established rheumatoid arthritis","volume":"89","author":"Amri M.","year":"2011","journal-title":"Tunis. Med."},{"key":"e_1_2_9_142_1","first-page":"70","article-title":"Anticitrullin antibodies\u2013modern markers of rheumatoid arthritis","volume":"83","author":"Shilkina N.P.","year":"2011","journal-title":"Ter. Arkh."},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101143"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.078063"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.57170"},{"key":"e_1_2_9_146_1","first-page":"12","article-title":"The role of anti\u2010cyclic citrullinated peptide antibodies in predicting rheumatoid arthritis","volume":"58","author":"Rexhepi S.","year":"2011","journal-title":"Reumatizam"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02640.x"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker217"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.81782"},{"key":"e_1_2_9_150_1","first-page":"466","article-title":"Anti\u2010cyclic citrullinated peptide antibodies and rheumatoid arthritis","volume":"58","author":"Hayashi N.","year":"2010","journal-title":"Rinsho. Byori"},{"key":"e_1_2_9_151_1","first-page":"S155","article-title":"Effects of arginine on hair damage via oxidative coloring process","volume":"55","author":"Oshimura E.","year":"2004","journal-title":"J. Cosmet. Sci."},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.04.061"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1472-8206.2012.01059.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1472-8206.2012.01059.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T20:37:44Z","timestamp":1697315864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1472-8206.2012.01059.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,31]]},"references-count":151,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1472-8206.2012.01059.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1472-8206.2012.01059.x","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,31]]},"assertion":[{"value":"2012-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}