{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:21:59Z","timestamp":1778869319909,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In past studies conducted by our group, riparin <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (rip <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>) isolated from the green fruit of <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>niba riparia<\/jats:italic> presented antianxiety effects in mice, while its analogs rip <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> showed anxiolytic and antidepressant\u2010like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>) and tail suspension test (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>) as predictive tests for antidepressant activity in rodents. In addition, the involvement of the monoaminergic system in this effect was also assessed. rip <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> was acutely administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50\u00a0mg\/kg. Results showed that rip <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> at both tested doses and administration routes produced a significant decrease in immobility time in <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>. The pretreatment of mice with prazosin (1\u00a0mg\/kg, i.p., an \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor antagonist), yohimbine (1\u00a0mg\/kg, i.p., an \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonist), <jats:styled-content style=\"fixed-case\">SCH<\/jats:styled-content>23390 (15\u00a0\u03bcg\/kg, i.p., a dopamine <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>1 receptor antagonist), sulpiride (50\u00a0mg\/kg, i.p., a dopamine <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>2 receptor antagonist), p\u2010chlorophenylalanine (100\u00a0mg\/kg, an inhibitor of serotonin synthesis) or ritanserin (4\u00a0mg\/kg, a serotonin 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\"><jats:sub>a<\/jats:sub><\/jats:styled-content>\/2<jats:styled-content style=\"fixed-case\"><jats:sub>c<\/jats:sub><\/jats:styled-content> receptor antagonist) blocked the anti\u2010immobility effects elicited by rip <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (50\u00a0mg\/kg, p.o.) in the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>. Taken together, results indicate that rip I produces significant antidepressant\u2010like activity in the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic and serotonergic systems.<\/jats:p>","DOI":"10.1111\/j.1472-8206.2012.01069.x","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T04:59:19Z","timestamp":1343105959000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Involvement of monoaminergic system in the antidepressant\u2010like effect of riparin <scp>I<\/scp> from <i><scp>A<\/scp>niba riparia<\/i> (<scp>N<\/scp>ees) <scp>M<\/scp>ez (<scp>L<\/scp>auraceae) in mice"],"prefix":"10.1111","volume":"28","author":[{"given":"Francisca Cl\u00e9a Floren\u00e7o","family":"de Sousa","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris Cristina Maia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Izabel Gomes","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Thiciane Vasconcelos","family":"de Melo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edvian Romero","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquell","family":"de Castro Chaves","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Lima","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley Juan Chaves","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutics Technology Federal University of Para\u00edba Jo\u00e3o Pessoa\u2010Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silv\u00e2nia Maria Mendes","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Silveira","family":"Mac\u00eado","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine Federal University of Cear\u00e1 Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza\u2010Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Maria Barbosa","family":"Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutics Technology Federal University of Para\u00edba Jo\u00e3o Pessoa\u2010Para\u00edba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"21","article-title":"Prevalence of mental disorders in Europe: results from the European Study of Epidemiology of Mental Disorders (ESEMeD) project","volume":"420","author":"Alonso J.","year":"2004","journal-title":"Acta Psychiatr. 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