{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:46:50Z","timestamp":1790232410267,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T00:00:00Z","timestamp":1157500800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Patients with rosacea and red facial skin often show sensitivity to skin care products which can exacerbate inflammation and subjective irritation. Besides pharmacologic management, special skin care is prudent to avoid cosmetically induced irritation and address cosmetic concerns. Appropriate skin care should provide gentle cleansing, UVA\/UVB protection, effective moisturization, and concealing pigments to neutralize the appearance of redness.<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> To evaluate skin compatibility and efficacy of a skin care regimen containing licochalcone A (Lic A), an anti\u2010irritant from the licorice plant <jats:italic>Glycyrrhiza inflata<\/jats:italic>, for subjects with mild to moderate facial redness.<\/jats:p><jats:p><jats:bold>Patients\/methods\u2002<\/jats:bold> Sixty\u2010two patients with mild to moderate red facial skin used a four\u2010product skin care regimen for 8\u00a0weeks. Clinical assessments of erythema and subjective irritation, cross\u2010polarized photography, and self\u2010assessment questionnaires were completed at baseline, and after 4 and 8\u00a0weeks of use. A quality of life questionnaire was given at baseline and week 8.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Clinical evaluations, subject response, and photography confirmed very good tolerability of the regimen and effective neutralization of redness by the pigmented products. Significant improvements in average erythema scores were observed at 4 and 8\u00a0weeks (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and an improvement in quality of life was confirmed by the patient questionnaires.<\/jats:p><jats:p><jats:bold>Discussion\u2002<\/jats:bold> The skin care regimen containing Lic A was found to be compatible with the sensitive facial skin of patients with rosacea and improved the appearance of persistent facial redness. The products were also observed to be compatible with daily metronidazole treatment.<\/jats:p>","DOI":"10.1111\/j.1473-2165.2006.00261.x","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T15:51:27Z","timestamp":1157557887000},"page":"227-232","source":"Crossref","is-referenced-by-count":69,"title":["Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A"],"prefix":"10.1111","volume":"5","author":[{"given":"T M","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R I","family":"Ceilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Buerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kolbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N S","family":"Trookman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R L","family":"Rizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schoelermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01216.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082564"},{"key":"e_1_2_5_4_2","first-page":"S12","article-title":"Advances in the topical treatment of acne and rosacea","volume":"3","author":"Ceilley RI","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.030"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.048"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1999.02.549"},{"key":"e_1_2_5_9_2","first-page":"183","article-title":"Facial hygiene and comprehensive management of rosacea","volume":"73","author":"Draelos ZD","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_5_10_2","first-page":"28","article-title":"Treating beyond the histology of rosacea","volume":"74","author":"Draelos ZD","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_5_11_2","first-page":"17","article-title":"Adjunctive skin care in the management of rosacea: cleansers, moisturizers, and photoprotectants","volume":"75","author":"Del Rosso JQ","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200405010-00009"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/archderm.1987.01660290077020","article-title":"Topical metronidazole. A review of its use in rosacea","volume":"123","author":"McClellan KJ","year":"1987","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.033"},{"key":"e_1_2_5_15_2","first-page":"27","article-title":"The pharmacologic therapy of rosacea: a paradigm shift in progress","volume":"75","author":"Bikowski JB","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04900.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.395"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","unstructured":"KolbeL ImmeyerJ BatzerJet al.Anti\u2010inflammatory efficacy of licochalcone A: correlation of anti\u2010irritative clinical potency and in vitro effects.Arch Dermatol Res2006;298:23\u201330.","DOI":"10.1007\/s00403-006-0654-4"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.348"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.386"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1473-2165.2006.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1473-2165.2006.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:32:48Z","timestamp":1697038368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1473-2165.2006.00261.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1473-2165.2006.00261.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1473-2165.2006.00261.x","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}