{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:28:57Z","timestamp":1791556137794,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Both glucosamine and its derivative N\u2010acetyl glucosamine are amino\u2010monosaccharides that serve key biochemical functions on their own and as substrate precursors for the biosynthesis of polymers such as glycosaminoglycans (e.g., hyaluronic acid) and for the production of proteoglycans. Glucosamine has an excellent safety profile and has been shown to provide benefits in several clinical disorders. Glucosamine compounds have been reported to have several beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acid synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation. Mechanistically, glucosamine also has both anti\u2010inflammatory and chondroprotective effects. Clinical trials have shown benefit in using oral glucosamine supplementation to improve symptoms and slow the progression of osteoarthritis in humans. Glucosamine has also been used to prevent and treat osteoarthritis in animals. Based on other observations, glucosamine has been suggested for additional clinical uses, including treatment of inflammatory bowel disease, migraine headaches, and viral infections. The current clinical uses for topical and oral glucosamine compounds and the mechanistic rationale for these uses are reviewed here.<\/jats:p>","DOI":"10.1111\/j.1473-2165.2006.00277.x","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T10:59:14Z","timestamp":1166785154000},"page":"309-315","source":"Crossref","is-referenced-by-count":73,"title":["Glucosamine: an ingredient with skin and other benefits"],"prefix":"10.1111","volume":"5","author":[{"given":"Donald L","family":"Bissett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,22]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"284","volume-title":"Biochemistry","author":"Stryer L","year":"1988"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080213"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199201000-00004"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X56510"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076017"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01540.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2004.09.002"},{"key":"e_1_2_7_9_2","first-page":"403","article-title":"Changes of glycosaminoglycan synthesis during in vitro ageing of human fibroblasts (WI\u201038)","volume":"8","author":"Schachtschabel DO","year":"1978","journal-title":"Aktuelle Gerontol"},{"key":"e_1_2_7_10_2","first-page":"AB106","article-title":"Topical N\u2010acetyl glucosamine and niacinamide increase hyaluronan in vitro","volume":"54","author":"Osborne R","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_7_11_2","first-page":"143","article-title":"Oral N\u2010acetylglucosamine supplementation improves skin conditions of female volunteers: clinical evaluation by a microscopic three\u2010dimensional skin surface analyzer","volume":"20","author":"Kikuchi K","year":"2002","journal-title":"J Appl Cosmetol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276601"},{"key":"e_1_2_7_13_2","first-page":"AB43","article-title":"Topical formulation containing N\u2010acetyl glucosamine and niacinamide reduces the appearance of photoaging on human facial skin","volume":"54","author":"Bissett D","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_7_14_2","first-page":"AB43","article-title":"Topical N\u2010acetyl glucosamine reduces the appearance of hyperpigmented spots on human facial skin. 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