{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:05:19Z","timestamp":1793322319568,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T00:00:00Z","timestamp":1187913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Injectable hyaluronic acid is a glycosaminoglycan used for soft\u2010tissue augmentation. A number of products that are not Food and Drug Administration (FDA) approved for use in the United States are used commonly in Europe. We report a case of persistent delayed\u2010type hypersensitivity to injected non\u2010animal\u2010stabilized hyaluronic acid. The patient was initially injected in Europe with a non\u2010FDA\u2010approved filler but traveled to the United States for evaluation of this adverse reaction.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A case of adverse reaction to non\u2010animal\u2010stabilized hyaluronic acid is described. An overview of selected hyaluronic acid filler products is provided.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The patient developed persistent facial edema after injection of hyaluronic acid filler to the melolabial folds, glabella, lips, and perioral rhytids.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Injectable hyaluronic acid can be associated with a variety of complications including immediate and delayed\u2010type hypersensitivity reactions. Physicians should be familiar with products used in other countries, as patients may present for evaluation following adverse reaction to fillers obtained abroad or from American physicians using non\u2010FDA\u2010approved products.<\/jats:p>","DOI":"10.1111\/j.1473-2165.2007.00331.x","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T11:09:18Z","timestamp":1187953758000},"page":"167-171","source":"Crossref","is-referenced-by-count":50,"title":["Persistent delayed\u2010type hypersensitivity reaction to injectable non\u2010animal\u2010stabilized hyaluronic acid"],"prefix":"10.1111","volume":"6","author":[{"given":"Sarah Tuttleton","family":"Arron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac M","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,24]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31166"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.039"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31251"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01251.x"},{"key":"e_1_2_4_6_2","unstructured":"Q\u2010Medical Sweden.Company Report. 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