{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:27:53Z","timestamp":1791509273900,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Skin redness is a common cosmetic concern affecting predominantly fair\u2010skin individuals and often leading to rosacea. On the basis of the current scientific knowledge of the physiological mechanisms underlying the problem, a complex and integral skin care serum (100RXED2025) was developed and tested clinically for efficacy.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Forty\u2010five healthy men and women volunteers, age 30\u201365, were recruited. All subjects had fair skin (phototype I, II, or III) and presented some degree of skin redness with telangiectasia on the cheeks, the nose, or the nose sides, at baseline. In the course of this open label study, subjects applied the test product on their face, twice daily for 56\u2003days. For each subject, skin redness was evaluated through colorimetric and visual analysis of photographs taken under cross\u2010polarized light at T\u2003=\u200328 (week 4) and T\u2003=\u200356 (week 8), then compared to baseline measurements obtained at day 0.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Forty\u2010four volunteers completed the study. On visual evaluation, skin redness had decreased in average by 32.2% at T\u2003=\u200328 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and by 48.0% at T\u2003=\u200356 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Importantly, 91% of the subjects showed improvement of skin redness at T\u2003=\u200328, reaching 100% at T\u2003=\u200356. Colorimetric analysis gave an average reduction in redness of 11.6% at T\u2003=\u200328 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and 13.7% at T\u2003=\u200356 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The anti\u2010redness efficacy of the test product was demonstrated after 28\u2003days with further increase following 56\u2003days of application.<\/jats:p>","DOI":"10.1111\/j.1473-2165.2012.00623.x","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T05:50:18Z","timestamp":1346651418000},"page":"207-212","source":"Crossref","is-referenced-by-count":9,"title":["Clinical efficacy of a serum integrating multiple cosmetic ingredients in the management of erythema of the face in aging skin"],"prefix":"10.1111","volume":"11","author":[{"given":"Eric","family":"Dupont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"L\u00e9veill\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Loigeret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Loing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Bilodeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006205-200509000-00006"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.007"},{"key":"e_1_2_5_4_2","first-page":"38","article-title":"Rosacea: a review","volume":"34","author":"Culp B","year":"2009","journal-title":"P T"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701485233"},{"key":"e_1_2_5_6_2","first-page":"214","article-title":"Diagnosis and treatment of rosacea","volume":"15","author":"Cohen AF","year":"2002","journal-title":"J Am Board Fam Pract"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.043349"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.01.012"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.101121"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235550"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.1.5"},{"issue":"1","key":"e_1_2_5_12_2","first-page":"5","article-title":"Rosacea as an inflammatory disorder: a unifying theory?","volume":"73","author":"Millikan LE","year":"2004","journal-title":"Cutis"},{"issue":"3","key":"e_1_2_5_13_2","first-page":"17","article-title":"Reactive oxygen species and rosacea","volume":"74","author":"Jones D","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03751.x"},{"key":"e_1_2_5_15_2","first-page":"50","article-title":"From hydration and cohesion to cell turnover: an integral approach to anti\u2010aging","volume":"125","author":"Dupont E","year":"2010","journal-title":"Cosmetics & Toiletries"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2000.006004230.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09894.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.048"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1473-2165.2012.00623.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1473-2165.2012.00623.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:19:26Z","timestamp":1697613566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1473-2165.2012.00623.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1473-2165.2012.00623.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1473-2165.2012.00623.x","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}