{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:37:09Z","timestamp":1771875429787,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T00:00:00Z","timestamp":1165881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Auton Autocoid Pharmacol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:bold>1<\/jats:bold>\u2002The present study was designed to investigate the relationship between innervation density and contractile responses to field stimulation and exogenous agonists at early time points after induction of bladder outlet obstruction (BOO) in rats.<\/jats:p><jats:p> <jats:bold>2<\/jats:bold>\u2002When compared with sham\u2010operated animals, 1, 3 and 7\u2003days of BOO were associated with a 75%, 80% and 90% increase of bladder weight. Field stimulation caused a frequency\u2010dependent increase in force of contraction. The force of contraction was reduced at each frequency in BOO rats with the greatest decrease after 1\u2003day and a gradual but incomplete recovery thereafter. In contrast, contractile responses to ATP, carbachol and KCl were markedly reduced after 1\u2003day of BOO and fully recovered after 7\u2003days. The neurofilament staining was not altered by 1\u2003day of BOO, but gradually decreased with increasing duration of BOO reaching the lowest levels after 7\u2003days.<\/jats:p><jats:p> <jats:bold>3<\/jats:bold>\u2002We conclude that impaired cellular contractility seems to underlie the early reductions of field stimulation\u2010induced contraction, possibly reflecting surgical trauma of the tissue. However, at later time points a reduced nerve density, possibly reflecting a partial denervation, appears to be the main reason for impaired contractile response to field stimulation.<\/jats:p>","DOI":"10.1111\/j.1474-8673.2006.00393.x","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T14:26:43Z","timestamp":1166020003000},"page":"47-53","source":"Crossref","is-referenced-by-count":30,"title":["Effect of short\u2010term outlet obstruction on rat bladder nerve density and contractility"],"prefix":"10.1111","volume":"27","author":[{"given":"M. M.","family":"Barendrecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chichester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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