{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:16:05Z","timestamp":1760645765907},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Auton Autocoid Pharmacol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:bold>1<\/jats:bold>\u2002A fructose\u2010enriched diet induces hypertension, metabolic alterations and insulin resistance in rats, resembling human metabolic syndrome. Previously, we found that prostanoid production was altered in fructose\u2010fed rats.<\/jats:p><jats:p> <jats:bold>2<\/jats:bold>\u2002This study analysed the effects of incubation with noradrenaline (NA) and angiotensin II (Ang II) on prostanoid release in mesenteric vascular beds from control and fructose\u2010fed rats. Animals which received fructose solution (10% w\/v) for 22\u2003weeks showed higher systolic blood pressure and triglyceridaemia.<\/jats:p><jats:p> <jats:bold>3<\/jats:bold>\u2002In controls, NA increased 6\u2010keto\u2010prostaglandin (PG) F<jats:sub>1<\/jats:sub>\u03b1 (prostacyclin metabolite) and thromboxane (TX) production. Ang II increased only TX release. In fructose\u2010fed animals, NA increased 6\u2010keto\u2010PG F<jats:sub>1<\/jats:sub>\u03b1 and TX. PGF<jats:sub>2<\/jats:sub>\u03b1 (vasoconstrictor) was also elevated. Ang II also increased PGF<jats:sub>2<\/jats:sub>\u03b1 and PGE<jats:sub>2<\/jats:sub> levels.<\/jats:p><jats:p> <jats:bold>4<\/jats:bold>\u2002In conclusion, in fructose rats Ang II <jats:italic>in vitro<\/jats:italic> stimulates a vasoconstrictor prostanoid not stimulated in controls. This could be related to the observed <jats:italic>in vivo<\/jats:italic> blood pressure increase. In fructose\u2010fed animals, NA and Ang II also augment vasodilator prostanoids, suggesting a compensatory mechanism because of long\u2010term hypertension.<\/jats:p>","DOI":"10.1111\/j.1474-8673.2007.00409.x","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T13:59:13Z","timestamp":1281535153000},"page":"161-165","source":"Crossref","is-referenced-by-count":4,"title":["Noradrenaline and angiotensin II modify vascular prostanoid release in fructose\u2010fed hypertensive rats"],"prefix":"10.1111","volume":"27","author":[{"given":"A. 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