{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:39:51Z","timestamp":1794591591920,"version":"4.9.1"},"reference-count":24,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T00:00:00Z","timestamp":1332288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Auton Autocoid Pharmacol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>1<\/jats:bold>The atypical opioid analgesic tramadol has been shown to provide beneficial clinical and urodynamic effects in patients with detrusor overactivity. The effect of tramadol on isolated detrusor muscle has not been studied. This study investigated the ability of tramadol to inhibit acetylcholine (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h)\u2010induced contractility of the isolated caprine (goat) detrusor muscle. The effect of three concentrations (30, 100 and 300\u00a0\u03bc<jats:sc>m<\/jats:sc>) of tramadol on 10 caprine detrusor strips contracted by the addition of 100, 200 or 400\u00a0\u03bc<jats:sc>m<\/jats:sc><jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h was studied. The sensitivity of tramadol\u2010induced inhibition of<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h responses to treatment with the \u03b2\u2010adrenoceptor antagonist propranolol (1\u00a0\u03bc<jats:sc>m<\/jats:sc>) and the opioid receptor antagonist naloxone (100\u00a0\u03bc<jats:sc>\u03bc<\/jats:sc>) was also studied.<\/jats:p><jats:p><jats:bold>2<\/jats:bold>Tramadol caused a concentration\u2010dependent inhibition of<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h\u2010induced detrusor contraction that was reversed by raising the concentration of<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h. Propranolol, but not naloxone, reversed the tramadol\u2010induced inhibition of contractions to<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h in the detrusor.<\/jats:p><jats:p><jats:bold>3<\/jats:bold>These results suggest that tramadol inhibits<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>h\u2010induced contractility of the isolated detrusor. They also suggest that tramadol does so by an indirect anticholinergic mechanism involving the stimulation of \u03b2\u2010adrenoceptors. Tramadol may be useful in managing clinical conditions requiring relaxation of the detrusor muscle. Although the concentrations of tramadol needed to relax the detrusor were relatively high, these could be clinically attained via intravesical administration.<\/jats:p>","DOI":"10.1111\/j.1474-8673.2012.00470.x","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T06:38:03Z","timestamp":1330497483000},"page":"15-22","source":"Crossref","is-referenced-by-count":7,"title":["Tramadol inhibits the contractility of isolated caprine detrusor muscle"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Kumar","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Clinical Pharmacology Christian Medical College Vellore 632 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Prabha","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Clinical Pharmacology Christian Medical College Vellore 632 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Paul","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Clinical Pharmacology Christian Medical College Vellore 632 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. X.","family":"Margaret Shanthi","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Clinical Pharmacology Christian Medical College Vellore 632 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"George","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Christian Medical College Vellore 632 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Peedicayil","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Clinical Pharmacology Christian Medical College Vellore 632 002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ernest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.11182"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705017"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"The future of bladder control \u2013 Intravesical drug delivery, a pinch of pepper, and gene therapy","volume":"4","author":"Fraser M.O.","year":"2002","journal-title":"Rev. Urol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.2009.00447.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706604"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00581-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-7-5"},{"key":"e_1_2_7_10_1","first-page":"e181","article-title":"State of the art in intravesical therapy for lower urinary tract symptoms","volume":"12","author":"Kaufman J.","year":"2010","journal-title":"Rev. Urol."},{"key":"e_1_2_7_11_1","first-page":"385","article-title":"High\u2010concentration tramadol\u2010induced vasodilation in rabbit aorta is mediated by both endothelium\u2010dependent and \u2013independent mechanisms","volume":"24","author":"Kaya T.","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01168-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(09)70159-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705297"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701355"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2008.44.11.1308916"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.034"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02597.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00024"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200060010-00008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200211000-00031"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000225913.64876.d2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0022-3565(24)29325-3","article-title":"Inhibition by tramadol of muscarinic receptor\u2010induced responses in cultured adrenal medullary cells and in Xenopus laevis oocytes expressing cloned M1 receptors","volume":"299","author":"Shiraishi M.","year":"2001","journal-title":"J.Pharmacol.Exp.Ther."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0622-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.25.040185.002245"}],"container-title":["Autonomic and Autacoid Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1474-8673.2012.00470.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1474-8673.2012.00470.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T05:42:25Z","timestamp":1742622145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1474-8673.2012.00470.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,21]]},"references-count":24,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1474-8673.2012.00470.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1474-8673.2012.00470.x","archive":["Portico"],"relation":{},"ISSN":["1474-8665","1474-8673"],"issn-type":[{"value":"1474-8665","type":"print"},{"value":"1474-8673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,21]]}}}