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Treatment of acute ischemic stroke is one condition where a nitrone (NXY\u2010059) is in late phase 3 clinical trials now. Also presented is a summary of the most recent work we have accomplished on the anticancer activity of the nitrones in a hepatocellular carcinoma. The mechanistic basis of action of these compounds in several animal models is not yet understood at the molecular levels; however, it does appear clear that their anti\u2010inflammatory properties are central to their action, which is based on their ability to down\u2010regulate exacerbated signal transduction processes.<\/jats:p>","DOI":"10.1111\/j.1474-9726.2006.00189.x","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T15:50:20Z","timestamp":1138031420000},"page":"51-57","source":"Crossref","is-referenced-by-count":73,"title":["Nitrones as therapeutics in age\u2010related diseases"],"prefix":"10.1111","volume":"5","author":[{"given":"Robert A.","family":"Floyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250222"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520080106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2003.39.4.799404"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01050.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02641.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4240"},{"key":"e_1_2_8_8_1","unstructured":"CarneyJM FloydRA(1991) Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage. 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