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We report here that CR increases lifespan independently of all Sir2\u2010family proteins in yeast. Furthermore, we demonstrate that nicotinamide, an inhibitor of Sir2\u2010mediated deacetylation, interferes with lifespan extension from CR, but does so independent of Sir2, Hst1, Hst2, and Hst4. We also find that 5\u00a0m<jats:sc>m<\/jats:sc> nicotinamide, a concentration sufficient to inhibit other sirtuins, does not phenocopy deletion of <jats:italic>HST3<\/jats:italic>. Thus, we propose that lifespan extension by CR is independent of sirtuins and that nicotinamide has sirtuin\u2010independent effects on lifespan extension by CR.<\/jats:p>","DOI":"10.1111\/j.1474-9726.2006.00240.x","type":"journal-article","created":{"date-parts":[[2006,11,21]],"date-time":"2006-11-21T18:28:13Z","timestamp":1164133693000},"page":"505-514","source":"Crossref","is-referenced-by-count":99,"title":["Sirtuin\u2010independent effects of nicotinamide on lifespan extension from calorie restriction in yeast"],"prefix":"10.1111","volume":"5","author":[{"given":"Mitsuhiro","family":"Tsuchiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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