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Addressing this fundamental question will be critical for the development of effective vaccines for the rapidly rising older subpopulation that manifests increased prevalence of malignancies and infections. Therefore, we undertook the current study to investigate whether aging impairs toll\u2010like receptor (TLR) function in myeloid dendritic cells and whether this leads to reduced T\u2010cell priming. Our results demonstrate that innate TLR immune priming function of myeloid bone marrow derived and splenic dendritic cells (DC) is preserved with aging using both allogeneic and infectious murine experimental systems. In contrast, aging impairs <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> intrinsic T\u2010cell function. Therefore, our results demonstrate that myeloid DCs manifest preserved TLR\u2010mediated immune responses with aging. However, aging critically impairs intrinsic adaptive T\u2010cell function.<\/jats:p>","DOI":"10.1111\/j.1474-9726.2006.00245.x","type":"journal-article","created":{"date-parts":[[2006,11,21]],"date-time":"2006-11-21T18:28:13Z","timestamp":1164133693000},"page":"473-486","source":"Crossref","is-referenced-by-count":79,"title":["Murine myeloid dendritic cell\u2010dependent toll\u2010like receptor immunity is preserved with aging"],"prefix":"10.1111","volume":"5","author":[{"given":"Bethany M.","family":"Tesar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy E.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Unternaehrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil S.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmol","family":"Chandele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kaech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0604330"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.06.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0803389"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.07.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00329-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(95)02016-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/48.6.B231"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.5.M220"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.10.4288-4298.1996"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.4.1525"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20022151"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093616"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00087-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041395"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90184-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.152.8.3740"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.245"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3102"},{"key":"e_1_2_6_21_1","first-page":"OL683","article-title":"Changes with age in peritoneal macrophage functions. 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