{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:28:57Z","timestamp":1790807337005,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1624,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1111\/j.1474-9726.2011.00677.x","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T13:50:15Z","timestamp":1295617815000},"page":"368-382","source":"Crossref","is-referenced-by-count":65,"title":["Novel role of aquaporin-4 in CD4+\u2003CD25+ T regulatory cell development and severity of Parkinson\u2019s disease"],"prefix":"10.1111","volume":"10","author":[{"given":"Ying","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,22]]},"reference":[{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10540-005-2577-2","article-title":"Nobel Lecture. Aquaporin water channels","volume":"24","author":"Agre","year":"2004","journal-title":"Biosci. Rep."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.184.2.387","article-title":"Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation","volume":"184","author":"Asano","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00004647-200204000-00001","article-title":"Aquaporins in brain: distribution, physiology, and pathophysiology","volume":"22","author":"Badaut","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1073\/pnas.0400569101","article-title":"Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson\u2019s disease","volume":"101","author":"Benner","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"e1376","DOI":"10.1371\/journal.pone.0001376","article-title":"Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons","volume":"3","author":"Benner","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00001756-200402090-00009","article-title":"Increased seizure threshold in mice lacking aquaporin-4 water channels","volume":"15","author":"Binder","year":"2004","journal-title":"Neuroreport"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/glia.20318","article-title":"Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels","volume":"53","author":"Binder","year":"2006","journal-title":"Glia"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-211-45295-0_23","article-title":"Nongenetic causes of Parkinson\u2019s disease","volume":"70","author":"Chade","year":"2006","journal-title":"J. Neural Transm."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archneur.60.8.1059","article-title":"Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease","volume":"60","author":"Chen","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.20682","article-title":"Nonsteroidal antiinflammatory drug use and the risk for Parkinson\u2019s disease","volume":"58","author":"Chen","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0192-0561(92)90070-2","article-title":"Effects of MPTP and vitamin E treatments on immune function in mice","volume":"14","author":"Chi","year":"1992","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1523\/JNEUROSCI.0970-05.2005","article-title":"Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson\u2019s disease in mice","volume":"25","author":"Choi","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/neur.1996.0020","article-title":"Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson\u2019s disease mice model","volume":"5","author":"Czlonkowska","year":"1996","journal-title":"Neurodegeneration"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jneuroim.2006.03.027","article-title":"Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases","volume":"176","author":"Dhib-Jalbut","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1073\/pnas.251341998","article-title":"Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson\u2019s disease","volume":"98","author":"Du","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jnr.20664","article-title":"Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice","volume":"82","author":"Fan","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.neurobiolaging.2007.02.015","article-title":"Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation","volume":"29","author":"Fan","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+\u2003CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1084\/jem.20050784","article-title":"Developmental regulation of Foxp3 expression during ontogeny","volume":"202","author":"Fontenot","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1046\/j.1471-4159.2002.00928.x","article-title":"Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson\u2019s disease","volume":"81","author":"Gao","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1523\/JNEUROSCI.23-15-06181.2003","article-title":"Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons","volume":"23","author":"Gao","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0022-3565(25)22504-6","article-title":"Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium","volume":"270","author":"Giovanni","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.neuro.22.1.219","article-title":"Microglia as mediators of inflammatory and degenerative diseases","volume":"22","author":"Gonzalez-Scarano","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1016\/S0021-9258(17)37486-0","article-title":"Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues","volume":"269","author":"Hasegawa","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0065-2776(03)81008-8","article-title":"Control of autoimmunity by naturally arising regulatory CD4+ T cells","volume":"81","author":"Hori","year":"2003","journal-title":"Adv. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0306-4522(01)00562-0","article-title":"Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration","volume":"110","author":"Iravani","year":"2002","journal-title":"Neuroscience"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.4049\/jimmunol.172.11.7015","article-title":"TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity","volume":"172","author":"Kim","year":"2004","journal-title":"J. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1006\/mcne.2000.0914","article-title":"Inflammatory regulators in Parkinson\u2019s disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2","volume":"16","author":"Knott","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.intimp.2004.05.006","article-title":"Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson\u2019s disease","volume":"4","author":"Kurkowska-Jastrzebska","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel","volume":"202","author":"Lennon","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","article-title":"Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease","volume":"5","author":"Liberatore","year":"1999","journal-title":"Nat. Med."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"E606","DOI":"10.1208\/aapsj080369","article-title":"Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson\u2019s disease","volume":"8","author":"Liu","year":"2006","journal-title":"AAPS J."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1055\/s-2006-951621","article-title":"Clinical implications of Parkinson\u2019s disease genetics","volume":"26","author":"Lorincz","year":"2006","journal-title":"Semin. Neurol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/311464a0","article-title":"Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism","volume":"311","author":"Markey","year":"1984","journal-title":"Nature"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0301-0082(98)00014-8","article-title":"Inflammation in the CNS: balance between immunological privilege and immune responses","volume":"56","author":"Matyszak","year":"1998","journal-title":"Prog. Neurobiol."},{"issue":"Suppl. 1","key":"10.1111\/j.1474-9726.2011.00677.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.01.005","article-title":"Inflammation and neurodegeneration in Parkinson\u2019s disease","volume":"10","author":"McGeer","year":"2004","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1189\/jlb.0807575","article-title":"Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia","volume":"83","author":"Ng","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.22.1.123","article-title":"Etiology and pathogenesis of Parkinson\u2019s disease","volume":"22","author":"Olanow","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/em.10133","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced lipid peroxidation and DNA damage in mouse bone marrow and blood","volume":"41","author":"Ortiz","year":"2003","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1082031","article-title":"Immunology. Regulating the regulators","volume":"299","author":"Powrie","year":"2003","journal-title":"Science"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB47|cit47","first-page":"135","article-title":"The parkinsonian toxin MPTP: action and mechanism","volume":"16","author":"Przedborski","year":"2000","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1046\/j.1471-4159.2001.00183.x","article-title":"The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety","volume":"76","author":"Przedborski","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1023\/B:JOBB.0000041771.66775.d5","article-title":"MPTP as a mitochondrial neurotoxic model of Parkinson\u2019s disease","volume":"36","author":"Przedborski","year":"2004","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00005072-199407000-00002","article-title":"Multiple sclerosis: immune system molecule expression in the central nervous system","volume":"53","author":"Raine","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/1359-6101(96)00003-2","article-title":"Chemokines in immune-mediated inflammation of the central nervous system","volume":"7","author":"Ransohoff","year":"1996","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB52|cit52","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1189\/jlb.0507296","article-title":"Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson\u2019s disease","volume":"82","author":"Reynolds","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB53|cit53","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.0803982","article-title":"Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets","volume":"182","author":"Reynolds","year":"2009","journal-title":"J. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB54|cit54","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.4049\/jimmunol.0901852","article-title":"Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson\u2019s disease","volume":"184","author":"Reynolds","year":"2010","journal-title":"J. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB55|cit55","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB56|cit56","first-page":"389","article-title":"CD4+ CD25+ suppressor T cells: more questions than answers","volume":"2","author":"Shevach","year":"2002","journal-title":"Nat. Rev."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB57|cit57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbrainres.2004.09.017","article-title":"The MPTP model of Parkinson\u2019s disease","volume":"134","author":"Smeyne","year":"2005","journal-title":"Brain Res."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB58|cit58","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.4049\/jimmunol.160.3.1212","article-title":"CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells","volume":"160","author":"Suri-Payer","year":"1998","journal-title":"J. Immunol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB59|cit59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.proghi.2004.03.001","article-title":"Aquaporins: water channel proteins of the cell membrane","volume":"39","author":"Takata","year":"2004","journal-title":"Prog. Histochem. Cytochem."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB60|cit60","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1098-2396(200102)39:2<167::AID-SYN8>3.0.CO;2-U","article-title":"Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson\u2019s disease","volume":"39","author":"Teismann","year":"2001","journal-title":"Synapse"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB61|cit61","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1073\/pnas.0837397100","article-title":"Cyclooxygenase-2 is instrumental in Parkinson\u2019s disease neurodegeneration","volume":"100","author":"Teismann","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB62|cit62","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1471-4159.2006.04315.x","article-title":"Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson\u2019s disease","volume":"100","author":"Thomas","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB63|cit63","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(85)91729-5","article-title":"Normal MPTP binding in parkinsonian substantial nigra: evidence for extraneuronal toxin conversion in human brain","volume":"1","author":"Uhl","year":"1985","journal-title":"Lancet"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB64|cit64","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0306-4522(99)00182-7","article-title":"Detailed localization of aquaporin-4 messenger RNA in the CNS: preferential expression in periventricular organs","volume":"94","author":"Venero","year":"1999","journal-title":"Neuroscience"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB65|cit65","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1242\/jcs.02519","article-title":"More than just water channels: unexpected cellular roles of aquaporins","volume":"118","author":"Verkman","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB66|cit66","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0197-4580(93)90112-O","article-title":"New stereological methods for counting neurons","volume":"14","author":"West","year":"1993","journal-title":"Neurobiol. Aging"},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB67|cit67","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002","article-title":"Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease","volume":"22","author":"Wu","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB68|cit68","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00427222","article-title":"Lewy bodies in Parkinson\u2019s disease are recognized by antibodies to complement proteins","volume":"84","author":"Yamada","year":"1992","journal-title":"Acta Neuropathol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB69|cit69","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.270.39.22907","article-title":"cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units","volume":"270","author":"Yang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB70|cit70","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0079-6123(06)61012-1","article-title":"Aquaporins: role in cerebral edema and brain water balance","volume":"161","author":"Zador","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB71|cit71","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-540-79885-9_7","article-title":"Role of aquaporin-4 in cerebral edema and stroke","volume":"190","author":"Zador","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1111\/j.1474-9726.2011.00677.x-BIB72|cit72","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1096\/fj.04-2751com","article-title":"Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson\u2019s disease","volume":"19","author":"Zhang","year":"2005","journal-title":"FASEB J."}],"container-title":["Aging Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1474-9726.2011.00677.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1474-9726.2011.00677.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:48:19Z","timestamp":1740876499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1474-9726.2011.00677.x"}},"subtitle":["AQP4 in Treg cell development and severity of PD"],"short-title":[],"issued":{"date-parts":[[2011,3,22]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1474-9726.2011.00677.x","relation":{},"ISSN":["1474-9718"],"issn-type":[{"value":"1474-9718","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3,22]]}}}