{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:53:26Z","timestamp":1790830406070,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T00:00:00Z","timestamp":1322438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Aging and age\u2010related diseases can be viewed as the result of the lifelong accumulation of stress insults. The identification of mutant strains and genes that are responsive to stress and can alter longevity profiles provides new therapeutic targets for age\u2010related diseases. Here we reported that a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    strain with reduced expression of\n                    <jats:italic>ribose\u20105\u2010phosphate isomerase<\/jats:italic>\n                    (\n                    <jats:italic>rpi<\/jats:italic>\n                    ),\n                    <jats:italic>EP2456<\/jats:italic>\n                    , exhibits increased resistance to oxidative stress and enhanced lifespan. In addition, the strain also displays higher levels of NADPH. The knockdown of\n                    <jats:italic>rpi<\/jats:italic>\n                    in neurons by double\u2010stranded RNA interference recapitulated the lifespan extension and oxidative stress resistance in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . This manipulation was also found to ameliorate the effects of genetic manipulations aimed at creating a model for studying Huntington\u2019s disease by overexpression of polyglutamine in the eye, suggesting that modulating\n                    <jats:italic>rpi<\/jats:italic>\n                    levels could serve as a treatment for normal aging as well as for polyglutamine neurotoxicity.\n                  <\/jats:p>","DOI":"10.1111\/j.1474-9726.2011.00762.x","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T13:03:46Z","timestamp":1320066226000},"page":"93-103","source":"Crossref","is-referenced-by-count":32,"title":["Reduced neuronal expression of ribose\u20105\u2010phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in\n                    <i>Drosophila<\/i>"],"prefix":"10.1111","volume":"11","author":[{"given":"Ching\u2010Tzu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Li","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyong\u2010Jhih","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Kang","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Ci","family":"Ciou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiou\u2010Hwa","family":"Yuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore 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