{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:16:25Z","timestamp":1764173785351},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T00:00:00Z","timestamp":1322438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Cell"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for aging\u2010associated immunological alterations in the design of new cancer immunotherapies. We thus compared immune populations in young and aged mice and found that B7\u2010DC<jats:sup>+<\/jats:sup> (PD\u2010L2\/CD273) B cells, a minor population in young mice, were significantly increased in aged mice. Induction of both Th1 and Th17 cells was significantly augmented by B7\u2010DC<jats:sup>+<\/jats:sup> B cells from aged mice, and this effect was blocked with anti\u2010B7\u2010DC antibodies <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Moreover, retardation of tumor growth in aged mice was largely B7\u2010DC dependent. Tumor growth in young mice was significantly inhibited by immunization with B7\u2010DC<jats:sup>+<\/jats:sup> B cells from aged mice owing to increased induction of tumor antigen\u2010specific cytotoxic T lymphocytes. These data indicate that B7\u2010DC<jats:sup>+<\/jats:sup> B cells could play an important role in aging\u2010associated cancer immunopathology as well as in other aging\u2010associated diseases and further suggest that B7\u2010DC<jats:sup>+<\/jats:sup> B cells have potential for future cancer immunotherapy.<\/jats:p>","DOI":"10.1111\/j.1474-9726.2011.00764.x","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T13:29:27Z","timestamp":1320154167000},"page":"128-138","source":"Crossref","is-referenced-by-count":23,"title":["Aging\u2010associated B7\u2010DC<sup>+<\/sup> B cells enhance anti\u2010tumor immunity via Th1 and Th17 induction"],"prefix":"10.1111","volume":"11","author":[{"given":"Kei","family":"Tomihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent 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