{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:57:34Z","timestamp":1774123054017,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:00:00Z","timestamp":1140652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sickle cell trait (SCT) is a genetic disease affecting the synthesis of normal haemoglobin (Hb) and marked by the heterozygous presence of HbA and HbS. Some studies have suggested that SCT carriers might be prone to vascular alterations, cardiac ischaemia and arrhythmias leading, in some subjects, to sudden death. It is well known that a loss or a disequilibrium of autonomic activity are powerful predictors of sudden cardiac death. We hypothesized that SCT subjects might exhibit alterations in the activity of the autonomic nervous system that could constitute further risk factors for cardiac complications. Resting haemorheological parameters (<jats:italic>\u03b7<\/jats:italic><jats:sub>b<\/jats:sub>, blood viscosity; <jats:italic>\u03b7<\/jats:italic><jats:sub>p<\/jats:sub>, plasma viscosity; Hct, haematocrit; Tk, red blood cell rigidity), and sympathetic and parasympathetic indices of nocturnal autonomic activity (temporal and frequency analysis of heart rate variability) were thus compared between a group of nine SCT subjects and a group of nine control subjects. <jats:italic>\u03b7<\/jats:italic><jats:sub>b<\/jats:sub> was higher in the SCT group than in the control group while Hct, <jats:italic>\u03b7<\/jats:italic><jats:sub>p<\/jats:sub> and Tk were not different. Global variability (SDNN, SDNNIDX) and parasympathetic (PNN50, RMSSD, HF) indices were significantly lower in the SCT group compared with the control group, while the LF\/HF ratio was highly increased, underlining a major sympathetic shift. The autonomic imbalance in SCT subjects was mainly related to lowered parasympathetic activity. Thus, our study suggests an additional global decrease and imbalance of autonomic nervous system activity to biological disorders of SCT carriers, that may constitute further risk factors for cardiac complications in this population.<\/jats:p>","DOI":"10.1111\/j.1475-097x.2006.00655.x","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T10:14:45Z","timestamp":1140689685000},"page":"87-91","source":"Crossref","is-referenced-by-count":26,"title":["Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers"],"prefix":"10.1111","volume":"26","author":[{"given":"Philippe","family":"Connes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Barthelemy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9raldine","family":"Monchanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Atchou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Forsuh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Massarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieudonn\u00e9","family":"Wouassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Thiriet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Pichot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1002","article-title":"Responses to exercise in children with sickle cell trait","volume":"136","author":"Alpert BS","year":"1982","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.065"},{"key":"e_1_2_6_4_1","first-page":"121","article-title":"The role of hemorheologic factors in the coronary circulation","volume":"11","author":"Baskurt OK","year":"1991","journal-title":"Clin Hemorheol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00027.x"},{"key":"e_1_2_6_6_1","first-page":"89","article-title":"The triphasic effects of exercise on blood rheology: which relevance to physiology and pathophysiology","volume":"19","author":"Brun JF","year":"1998","journal-title":"Clin Hemorheol Microcirc"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00566.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92558-8"},{"key":"e_1_2_6_9_1","first-page":"241","article-title":"Red cell rigidity, Tk, and filtration","volume":"5","author":"Dintenfass L","year":"1985","journal-title":"Clin Hemorheol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331977702801108"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(03)00220-0"},{"key":"e_1_2_6_12_1","first-page":"197","article-title":"Flow behaviour of rigid red blood cells in the microcirculation","volume":"3","author":"Driessen GK","year":"1984","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202043060504"},{"key":"e_1_2_6_14_1","first-page":"1975","article-title":"Left ventricule function and sickle\u2010cell anemia. Echocardiographic study","volume":"82","author":"Estrade G","year":"1989","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.1.H261"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810060109"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199212000-00004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00614.2001"},{"key":"e_1_2_6_19_1","first-page":"507","article-title":"Sickle cells and sudden death: morphologic abnormalities of the cardiac conduction system","volume":"124","author":"James TN","year":"1994","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2003.10.009"},{"key":"e_1_2_6_21_1","first-page":"1472","article-title":"Sickle cell trait and sudden death in athletes","volume":"276","author":"Kerle KK","year":"1996","journal-title":"JAMA"},{"key":"e_1_2_6_22_1","first-page":"2648","article-title":"Role of arterial O2 flow in peripheral chemoreceptor excitation","volume":"39","author":"Lahiri S","year":"1980","journal-title":"Fed Proc"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.51.19"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000170128.78432.96"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.1826"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(94)80005-7"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200210000-00019"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02308838"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/jappl.1995.78.3.763","article-title":"Invited editorial on \u2018Effect of RBC shape and deformability on pulmonary O2 diffusing capacity and resistance to flow in rabbit lungs\u2019","volume":"78","author":"Sarelius IH","year":"1995","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/1040-8428(90)90020-S"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00452.2003"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS14982J"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1475-097X.2006.00655.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1475-097X.2006.00655.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T21:35:07Z","timestamp":1695936907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1475-097X.2006.00655.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,23]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1475-097X.2006.00655.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1475-097x.2006.00655.x","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,23]]}}}