{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:28:21Z","timestamp":1780111701466,"version":"3.54.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Positron emission tomography (PET) with [<jats:sup>15<\/jats:sup>O]\u2010H<jats:sub>2<\/jats:sub>O\u2010PET (WAT\u2010PET) or [<jats:sup>11<\/jats:sup>C]\u2010acetate (AC\u2010PET) quantifies myocardial perfusion and oxidative metabolism, but routine clinical use is hampered by the need for additional investigations to assess cardiac performance.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To apply classical tracer kinetics to dynamic PET could provide important haemodynamic parameters.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> First\u2010pass PET data were used with indicator dilution techniques to measure stroke volume index (SVI). Early pulmonary retention of [<jats:sup>11<\/jats:sup>C]\u2010acetate was converted to standard uptake values (SUV) (Lung<jats:sub>AC\u2010SUV<\/jats:sub>). Regional lung water (rLW) content was computed from the WAT\u2010PET scan at equilibrium. PET was compared with radionuclide angiography and echocardiography in patients with ischaemic cardiomyopathy with New York Heart Association class II (<jats:italic>n<\/jats:italic>\u2003=\u200310) or III (<jats:italic>n<\/jats:italic>\u2003=\u200318) congestive heart failure. Elderly male volunteers without heart disease (<jats:italic>n<\/jats:italic>\u2003=\u200311) underwent AC\u2010PET as controls.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> SVI with both tracers correlated in patients (<jats:italic>r<\/jats:italic>\u2003=\u20030\u00b791, <jats:italic>P<\/jats:italic>&lt;0\u00b7001, estimated standard error =\u20034\u2003ml\u2003m<jats:sup>\u22122<\/jats:sup>) and with left ventricular ejection fraction (both tracers <jats:italic>r<\/jats:italic>&gt;0\u00b76, <jats:italic>P<\/jats:italic>&lt;0\u00b7001). SVI was significantly different between all groups (ANOVA: <jats:italic>P<\/jats:italic>&lt;0\u00b7001). Lung<jats:sub>AC\u2010SUV<\/jats:sub> correlated with rLW (<jats:italic>r<\/jats:italic>\u2003=\u20030\u00b778, <jats:italic>P<\/jats:italic>&lt;0\u00b7001) and both were elevated in severe heart failure (<jats:italic>P<\/jats:italic>&lt;0\u00b705 for both). Elevated Lung<jats:sub>AC\u2010SUV<\/jats:sub> was associated with a restrictive left ventricular (LV) filling pattern by Doppler echocardiography.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Dynamic PET with first\u2010pass analysis and tracers of myocardial perfusion enables quantification of the haemodynamic consequences of LV systolic and diastolic dysfunctions in ischaemic cardiomyopathy and could be useful in the evaluation of the central circulation in heart failure.<\/jats:p>","DOI":"10.1111\/j.1475-097x.2006.00670.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T18:40:30Z","timestamp":1145990430000},"page":"171-177","source":"Crossref","is-referenced-by-count":11,"title":["The central circulation in congestive heart failure non\u2010invasively evaluated with dynamic positron emission tomography"],"prefix":"10.1111","volume":"26","author":[{"given":"Jens","family":"S\u00f6rensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Andr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Blomquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"St\u00e5hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"L\u00e5ngstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Hedenstierna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,25]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Heart Disease. A Textbook of Cardiovascular Medicine","author":"Braunwald E","year":"1997"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(02)00023-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200205000-00007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00384-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.1.104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000472"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc342"},{"key":"e_1_2_6_9_1","volume-title":"Heart and Circulation. Geigy Scientific Tables","author":"Lentner C","year":"1990"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90677-5"},{"key":"e_1_2_6_11_1","first-page":"693","article-title":"Myocardial perfusion imaging with PET","volume":"35","author":"Schwaiger M","year":"1994","journal-title":"J Nucl Med"},{"key":"e_1_2_6_12_1","first-page":"1176","article-title":"Simple and accurate assessment of forward cardiac output by use of [1\u201011C]acetate PET verified in a pig model","volume":"44","author":"S\u00f6rensen J","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_6_13_1","first-page":"1174","article-title":"[1\u2010(11)C]acetate as a quantitative perfusion tracer in myocardial PET","volume":"42","author":"Van Den Hoff J","year":"2001","journal-title":"J Nucl Med"},{"key":"e_1_2_6_14_1","first-page":"719","article-title":"Regional lung water measurements with PET: accuracy, reproducibility, and linearity","volume":"32","author":"Velazquez M","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1102.105289"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1475-097X.2006.00670.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1475-097X.2006.00670.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:27:56Z","timestamp":1697056076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1475-097X.2006.00670.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,25]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1475-097X.2006.00670.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1475-097x.2006.00670.x","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,25]]}}}