{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T16:17:25Z","timestamp":1697645845244},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Introduction\u2002<\/jats:bold> Liver\u2010type fatty acid binding proteins (L\u2010FABP) have been shown to be present in alveolar macrophages and type II pneumocytes of the lung. This study determined levels of L\u2010FABP in serum and broncho\u2010alveolar lavage (BAL) during experimental acute respiratory failure (ARF) to evaluate whether this molecule can serve as a marker for lung damage.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Male Sprague\u2013Dawley rats (<jats:italic>n<\/jats:italic>\u2003=\u200324) were ventilated and either lung lavaged or lavaged and treated with surfactant, and compared to ventilated, non\u2010lavaged controls. Blood samples were drawn every hour for 4\u2003h to measure L\u2010FABP concentrations in serum. At the end of the experiment a BAL was performed to determine L\u2010FABP levels in BAL fluid. L\u2010FABP was measured with a sandwich enzyme\u2010linked immunosorbent assays.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Serum L\u2010FABP concentrations rose significantly during the first 2\u2003h of ventilation in all groups compared with baseline values. After 2\u2003h L\u2010FABP levels were significantly higher in lavaged animals compared with the ventilated controls and to animals treated with surfactant. After 4\u2003h of ventilation, L\u2010FABP in BAL was significantly higher in lavaged, non\u2010surfactant treated animals compared with the ventilated controls.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In the early phase of experimental ARF serum L\u2010FABP levels correlate well with the degree of lung injury.<\/jats:p>","DOI":"10.1111\/j.1475-097x.2006.00703.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T08:25:54Z","timestamp":1161159954000},"page":"371-375","source":"Crossref","is-referenced-by-count":8,"title":["Liver\u2010type fatty acid binding protein in serum and broncho\u2010alveolar lavage in a model of acute respiratory failure because of surfactant depletion \u2013 a possible marker for lung damage?"],"prefix":"10.1111","volume":"26","author":[{"given":"R. A.","family":"Lachmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Werchan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schachtrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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