{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:58:51Z","timestamp":1773917931901,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T00:00:00Z","timestamp":1314144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The goal of the study is to correlate serum calcium levels with the results of dual\u2010phase <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi parathyroid scintigraphy to find the best cut\u2010off level of the serum calcium that correlates with a positive presurgery.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In 111 patients, serum calcium and plasma parathormone (PTH) levels were compared with the results of the <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy and with this data determined the level of calcium above which the <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy was likely to be positive and below which the study was likely to be negative.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In total, 11 men (18%) and 50 women (82%) had a positive <jats:sup>99m<\/jats:sup>Tc\u2010MIBI study. Overall 67% of those patients with a positive <jats:sup>99m<\/jats:sup>Tc\u2010MIBI study had a PTH &gt;200\u2003ng\u2003l<jats:sup>\u22121<\/jats:sup> compared to only 9% of those with a negative <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy; however, for those with a positive study on an early <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy, this rose to 85%. Overall a serum calcium of &gt;2\u00b770\u2003mmol\u2003l<jats:sup>\u22121<\/jats:sup> was found in 82% of patients with a positive <jats:sup>99m<\/jats:sup>Tc\u2010MIBI study but only 14% of those with a negative <jats:sup>99m<\/jats:sup>Tc\u2010MIBI study, this is rose to 97% of patients with a parathyroid adenoma identified on early images. It is also shown that patients whose serum total calcium &lt;2\u00b751\u2003mmol\u2003l<jats:sup>\u22121<\/jats:sup> rarely have positive <jats:sup>99m<\/jats:sup>Tc\u2010MIBI scintigraphy.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:sup>99m<\/jats:sup>Tc\u2010MIBI parathyroid scintigraphy is most likely to yield identification and localization of a parathyroid adenoma when both PTH and calcium are elevated; however, although there is no lower limit of PTH which can predict a negative study, we cannot recommend <jats:sup>99m<\/jats:sup>Tc\u2010MIBI parathyroid scintigraphy if the serum calcium is &lt;2\u00b751\u2003mmol\u2003l<jats:sup>\u22121<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/j.1475-097x.2011.01048.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T01:26:38Z","timestamp":1314840398000},"page":"19-24","source":"Crossref","is-referenced-by-count":21,"title":["Correlation between serum calcium levels and dual\u2010phase <sup>99m<\/sup>Tc\u2010sestamibi parathyroid scintigraphy in primary hyperparathyroidism"],"prefix":"10.1111","volume":"32","author":[{"given":"D. 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