{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:28:32Z","timestamp":1773278912580,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,11]],"date-time":"2012-03-11T00:00:00Z","timestamp":1331424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the development of lung function in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective cohort study, 88 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients had a lung function test performed and 63 patients (72%) had their <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content> repeated with a median follow\u2010up period of 4\u00b74\u00a0years. Forty\u2010eight per cent were smokers, and at the re\u2010examination, 97% were on combination antiretroviral therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non\u2010smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non\u2010smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non\u2010smokers at both examinations. <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> was reduced especially in smokers and declined in both smokers and non\u2010smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Carbon monoxide diffusion capacity is reduced in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients and seems to decline over time. Additionally, signs of obstructive lung disease are present in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients and seem to increase over time, although only modestly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1475-097x.2012.01124.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:50:25Z","timestamp":1331513425000},"page":"288-295","source":"Crossref","is-referenced-by-count":55,"title":["Changes in lung function of <scp>HIV<\/scp>\u2010infected patients: a 4\u00b75\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"32","author":[{"given":"Ulrik Sloth","family":"Kristoffersen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET Copenhagen University Hospital Copenhagen Denmark"},{"name":"Cluster for Molecular Imaging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Mette","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital, Hvidovre Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gerstoft","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Gutte","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET Copenhagen University Hospital Copenhagen Denmark"},{"name":"Cluster for Molecular Imaging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET Copenhagen University Hospital Copenhagen Denmark"},{"name":"Cluster for Molecular Imaging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200500186064"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0255.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.5.1326"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0836OC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-7-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-5-200003070-00006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.6.1977"},{"key":"e_1_2_8_9_1","article-title":"Association between obstructive lung disease and markers of HIV infection in a high\u2010risk cohort","author":"Drummond MB","year":"2011","journal-title":"Thorax"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006328"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1858OC"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200203000-00001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000226949.64600.f9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.05.009"},{"key":"e_1_2_8_15_1","first-page":"A2285","article-title":"Longitudinal Decline in Pulmonary Function in an HIV+ Cohort Studied in the Era of Highly Active Antiretroviral Therapy (HAART)","volume":"179","author":"Kadri S","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.2.390"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(97)90042-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2010019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.10.005"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1475-097X.2012.01124.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1475-097X.2012.01124.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T08:23:24Z","timestamp":1698740604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1475-097X.2012.01124.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,11]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1475-097X.2012.01124.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1475-097x.2012.01124.x","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,11]]}}}